Graduate Thesis Or Dissertation
 

Certain physiological and pharmacological effects of radiation on rabbits

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  • Data were taken, following irradiation exposure to 100r and 300r cumulative dose, on 89 rabbits of three breeds that vary greatly in body size. Hematological, intestinal motility, and ear vascularity examinations were performed. Least square estimates have been obtained and an analysis of variance has been conducted in order estimate the effects of breed, sex, radiation, and interaction of breed x sex, breed x radiation, sex x radiation, and breed x sex x radiation upon each of the 116 dependent variables used in this study. Breed differences were found for number of erythrocytes and the hemoglobin value wherein the smaller and intermediate breeds showed higher values than the larger breed. The larger breed presented higher blood creatinine. The Polish breed shoved a marked initial depression in scybala production compared to that of the other two breeds after saline. Morphine (1 mg/kg) produced a marked depression of scybala production in the Polish breed. With higher doses of morphine (2 mg/kg), the Polish and New Zealand breeds passed a fewer number of scybala than the Flemish Giant breed. The central artery of the ear of the New Zealand and Polish breeds responded more rapidly to the vasodilating effect of xylene. Normal male rabbits showed a higher number of erythrocytes and hemoglobin values. A significant reduction in number of leucocytes occurred one day after 100r until the 10th week post-irradiation period. The hematocrit values decreased air significantly until the 4th week post-irradiation period. Blood uric acid showed the highest degree of radio sensitivity. The Flemish Giant and Polish breeds showed a greater increase in blood creatine and uric acid one day after 100r as compared with the New Zealand breed. Severe reduction of erythrocytes indicative of anemia was observed after 300r. The anemia appeared to be normocytic. No recovery process was evident 10 weeks later. The leucocytes were severely reduced. The hemoglobin and hematocrit values exhibited a significant reduction one day after 300r. The blood creatinine, creatine and uric acid values were observed to increase reaching a maximum peak at about the 4th week. A cumulative dose of 300r potentiated a constipative effect. Control animals were more sensitive to the constipative effect of 1 mg/kg or morphine than the irradiated animals. Vasodilation of the central artery of the ear of the irradiated animals was observed. Leukopenia was more evident in the Flemish Giant breed after 300r, while the hematocrit values of this breed were the least affected by the irradiation. The New Zealand showed less increase in creatinine values compared to that of the Flemish Giant and Polish breeds. The constipative effect of a 300r cumulative dose was more evident in the broods possessing extreme variations in body size. Morphine (1 mg/kg) exerted a greater constipative effect on the Polish and Flemish Giant breeds. The central artery of the ear of the New Zealand breed was more sensitive to the vasodilating effects of 300r. After xylene, the Flemish Giant breed showed a marked vasodilation of the central artery of the ear as compared to that of the New Zealand and Polish breeds. The number of leucocytes and the hematocrit values showed greater reduction in the females after 300r. Males were more affected by irradiation with respect to the blood creatinine and creatine values. The number of scybala passed by the irradiated females was lower than that by the males. The scybala weights of the males were heavier.
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