Article
 

Causes of genome instability: the effect of low dose chemical exposures in modern society

Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/articles/8910jw32d

Descriptions

Attribute NameValues
Creator
Abstract
  • Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome’s integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced tendency for the genome to acquire mutations; ranging from changes to the nucleotide sequence to chromosomal gain, rearrangements or loss. This review raises the hypothesis that in addition to known human carcinogens, exposure to low dose of other chemicals present in our modern society could contribute to carcinogenesis by indirectly affecting genome stability. The selected chemicals with their mechanisms of action proposed to indirectly contribute to genome instability are: heavy metals (DNA repair, epigenetic modification, DNA damage signaling, telomere length), acrylamide (DNA repair, chromosome segregation), bisphenol A (epigenetic modification, DNA damage signaling, mitochondrial function, chromosome segregation), benomyl (chromosome segregation), quinones (epigenetic modification) and nano-sized particles (epigenetic pathways, mitochondrial function, chromosome segregation, telomere length). The purpose of this review is to describe the crucial aspects of genome instability, to outline the ways in which environmental chemicals can affect this cancer hallmark and to identify candidate chemicals for further study. The overall aim is to make scientists aware of the increasing need to unravel the underlying mechanisms via which chemicals at low doses can induce genome instability and thus promote carcinogenesis.
  • This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by Oxford University Press. The published article can be found at: http://carcin.oxfordjournals.org/. The publisher and the author(s) have made this article open access.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Langie, S. A. S., Koppen, G., Desaulniers, D., Al-Mulla, F., Al-Temaimi, R., Amedei, A., ... & Collins, A. R. (2015). Causes of genome instability: the effect of low dose chemical exposures in modern society. Carcinogenesis, 36(Suppl 1), S61-S88. doi:10.1093/carcin/bgv031
Journal Title
Journal Volume
  • 36
Journal Issue/Number
  • Supp. 1
Rights Statement
Funding Statement (additional comments about funding)
  • Flemish Institute for Technological Research (VITO, Belgium); National Institute of Health-National Institute of Environmental Health Sciences (R01ES017452 and travel grant support); University of Padova, Italy (prot. 60A07-5397/13, CONACyT #153781); Ministerio de Educación y Ciencia (‘Juan de la Cierva’programme, 2009) of the Spanish Government; Innoviris (NanoIris project); Belgian Science Policy Office (IUAP P7/07DevRepair); Research Fund Flanders, Belgium (FWO-Vlaanderen); Fondazione Cariplo (2011-0370 to C.M.); Kuwait Institute for the Advancement of Sciences (2011-1302-06 to F.Al-M.); Grant University Scheme (RUGs) Ministry of Education Malaysia (04-02-12-2099RU to R.A.H.); Italian Ministry of University and Research (2009FZZ4XM_002 to A.A.); University of Florence (ex60%2012 to A.A.); US Public Health Service Grants (RO1 CA92306, RO1CA92306-S1, RO1 CA113447 to R.R.); Department of Science and Technology, Government of India (SR/FT/LS-063/2008 to N.S.). Ann-Karin Olsen and Gunnar Brunborg were supported by the Research Council of Norway (RCN) through its Centres of Excellence funding scheme (223268/F50).
Publisher
Peer Reviewed
Language
Replaces

Relationships

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
file details BissonWilliamHEnvironmentalMolecularToxicologyCausesGenomeInstability.pdf 2017-07-26 Public Download