A Primer on Peroxiredoxin Biochemistry

Citeable URL: https://ir.library.oregonstate.edu/concern/articles/w6634543v

Descriptions

Attribute Name	Values
Creator	Karplus, P. Andrew
Abstract	Peroxiredoxins (Prxs) were not recognized as a family of enzymes until the 1990s but are now known to be the dominant peroxidases in most organisms. Here, the history and fundamental properties of peroxiredoxins are briefly reviewed, with a special focus on describing how an exquisitely tunable balance between fully folded and locally unfolded conformations plays a large role in peroxiredoxin catalytic properties. This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at: http://www.journals.elsevier.com/free-radical-biology-and-medicine/ Keywords: Oxidative stress, Chaperone, Hydrogen peroxide, Floodgate hypothesis, Redox signaling
Resource Type	Article
DOI	https://doi.org/10.1016/j.freeradbiomed.2014.10.009
Date Available	2015-08-04T22:49:04+00:00
Date Issued	2015-03
Citation	Karplus, P. A. (2015). A primer on peroxiredoxin biochemistry. Free Radical Biology and Medicine, 80, 183-190. doi:10.1016/j.freeradbiomed.2014.10.009
Journal Title	Free Radical Biology and Medicine
Journal Volume	80
Rights Statement	Copyright Not Evaluated
Funding Statement (additional comments about funding)	This study was supported in part by National Institutes of Health grant RO1 GM050389 to Leslie B. Poole and P.A.K.
Publisher	Elsevier
Peer Reviewed	Yes
Language	English [eng]
Replaces	http://hdl.handle.net/1957/56545