Graduate Thesis Or Dissertation
 

Digital Fourier Holographic Microscopy and Potential Applications Towards the Design of Photodynamic Therapy of Osteosarcoma

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/6h440x00s

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  • This work entails both imaging and therapeutic applications of biomedical optics. In both contexts, an understanding of light transport in tissues is necessary. An overview of optical transport in tissues is given, including scattering theory. Digital Fourier holographic microscopy is introduced and applied as a means of metrology via optical scatter imaging. The later portion of this work focuses on the clinical application of photodynamic therapy of osteosarcoma. A 3D Monte Carlo model is developed as a predictive model of clinical applications of photodynamic therapy in treating osteosarcoma within the medullary cavity of long bones. Prior to compiling the Monte Carlo model, optical properties of bone tissues are determined via diffuse reflectance spectroscopy.
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