Undergraduate Thesis Or Project
 

A Metabolomics Driven Investigation of Polyamine Metabolism During Adipogenesis

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https://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/vq27zq29m

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  • Obesity is achieved at the point where fat accumulation begins to exert deleterious effects on an organism. The human body accrues fat when there is an energy imbalance occurring, where caloric intake exceeds expenditure.Many anti-obesity drugs used in the past have had undesirable side effects, and currently there is a push to develop safer, nutraceutical agents, derived from natural products (Colitti & Grasso, 2014). Altered metabolic processes have been identified as influencing the progression of metabolic syndrome (Monickaraj et al., 2013). FAAs measured in fully differentiated adipose tissue after exogenous treatment with URB597 were not significantly different than those measured in the untreated DMSO control group. Data obtained regarding FAAs did not support nor disprove our hypothesis. Additionally, acetylated polyamines were not detected in cell lysates. The polyamines spermidine and spermine decreased with exogenous spermidine treatment, with log2 fold change values of -0.56 and -1.13, respectively. However, the polyamine putrescine was observed to change by 1.49 log2 fold, and the p-value associated with that change was less than 0.01, indicating high statistical significance.
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