Graduate Thesis Or Dissertation

 

The Pursuit of Hoppiness : Propelling Hop into the Genomic Era Public Deposited

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/sj139514b

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  • Hop (Humulus lupulus L. var lupulus) is a plant of great cultural significance, used as a medicinal herb for thousands of years, and for flavor and as a preservative in brewing beer. Studies of the medicinal effects of the unique compounds produced by hop have led to interest from the pharmacy and healthcare industries. Although many industries have interest in the plant itself and scientists are interested in the evolution of the Cannabaceae sex chromosomes, little effort has gone into developing genomic resources. H. lupulus is a highly heterozygous, repeat-rich, plant genome with a size of about 2.8 gigabases. This combination presents an immense challenge to studying the genomics of hop. Here we present, a web portal for studying hop genomics, a novel hop genome assembly, gene annotations for both draft genome assemblies, an evolutionary biology study regarding the hop sex chromosomes, and a novel way of modeling transcripts using deep learning. The combination of these manuscripts provides a framework for the future of hop genomics.
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