Browsing Electronic Theses and Dissertations by Subject "p53 protein"

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Control of p53 tumor suppressor and peroxiredoxin activity through shifts in cellular redox balance

Stoner, Christopher S. (2007-07-19)

Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox ...
Transactivational activity of the tumor suppressor protein p53 is dependent on thioredoxin reductase activity in mammalian cells

Merwin, Jason R. (2003-09-11)

Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. Thioredoxin reductase specifically catalyzes the NADPH-dependent reduction of thioredoxin. ...