Index Catalog // ScholarsArchive@OSU

Creator:: Chimploy, Korakod, Song, Shiwei, Wheeler, Linda J., and Mathews, Christopher K.
Abstract:: Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly asymmetric, and this asymmetry probably contributes toward the elevated mutation rate for the mitochondrial genome as compared with the nuclear genome. To understand this asymmetry, we must identify pathways for synthesis and accumulation of dNTPs within mitochondria. We have identified ribonucleotide reductase...
Resource Type:: Article

Creator:: Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Leonova, Katerina I., Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Berman, Albert E., Flanagan, Sheryl, Shewach, Donna S., Zeitouni, Nathalie C., Gudkov, Andrei V., Mathews, Christopher K., and Nikiforov, Mikhail A.
Abstract:: The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and ribonucleotide...
Resource Type:: Article

Creator:: Saldivar, Joshua C., Miuma, Satoshi, Bene, Jessica, Hosseini, Seyed Ali, Shibata, Hidetaka, Sun, Jin, Wheeler, Linda J., Mathews, Christopher K., and Huebner, Kay
Abstract:: Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration in preneoplasias is deletion within the fragile FRA3B/FHIT locus, leading to loss of Fhit protein expression....
Resource Type:: Article

Creator:: Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Natarajan, Venkatesh, Zucker, Shoshanna N., Fink, Emily E., Im, Michael, Flanagan, Sheryl, Burhans, William C., Zeitouni, Nathalie C., Shewach, Donna S., Mathews, Christopher K., and Nikiforov, Mikhail A.
Abstract:: In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response (DDR). Oxidative stress and hyper-replication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here we report that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage in...
Resource Type:: Article

Creator:: Schaaper, Roel M. and Mathews, Christopher K.
Abstract:: The accuracy of DNA synthesis depends on the accuracy of the polymerase as well as the quality and concentration(s) of the available 5'-deoxynucleoside-triphosphate DNA precursors (dNTPs). The relationships between dNTPs and error rates have been studied in vitro, but only limited insights exist into these correlations during in vivo replication....
Resource Type:: Article

Creator:: Wheeler, Linda J. and Mathews, Christopher K.
Abstract:: Saccharomyces cerevisiae contains three NAD⁺/NADH kinases, one of which is localized in mitochondria and phosphorylates NADH in preference to NAD⁺. Strand et al (Euk. Cell 2:809 (2003)) reported that a yeast mutation in POS5, which encodes the mitochondrial NADH kinase, is a mutator, specific for mitochondrial genes. Because of the...
Resource Type:: Article

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