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Filtering by: Academic Affiliation Biochemistry and Biophysics Date issued sim 2019-01-08

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

Creator:

Blizzard, Robert J.

Abstract:

The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...

Resource Type:

Dissertation