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Structural investigations to understand the mechanisms of two proteins involved in sulfur chemistry : SsuE and cysteine dioxygenase

Creator:: Driggers, Camden McCullough
Abstract:: Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
Resource Type:: Dissertation
Full Text:: studies of G- protein coupled receptors (2012, R. J. Lefkowitz and B. K. Kobilka) and the ribosome

Analysis of secondary structures in nucleic acid binding proteins and nuclear magnetic resonance investigation of helix propagation and residual motions in proteins

Creator:: Hicks, Joshua M.
Abstract:: This thesis involves analyses of 3₂-helices, a-helices and of the change in residual entropy of a protein upon chemical modification. Part of the long-term goal of understanding the formation, function and stability of proteins requires that all conformations be accurately assigned and structurally understood. By a statistical analysis of 258...
Resource Type:: Dissertation
Full Text:: their amino acids were found to exist as 32-helices. The third K homology domain, Epstein-Barr nuclear

The mechanism of interaction of the linker histone with DNA and nucleosomes

Creator:: Ellen, Thomas Patrick
Abstract:: This dissertation examines the interaction of the linker histone with DNA and with nucleosomes. The first goal of the project was to characterize the interaction of the linker histone with DNA. Three factors previously reported to influence the linker histone's interaction with DNA were examined: ratio of linker histone to...
Resource Type:: Dissertation
Full Text:: support he has shown me during the course of this work. Thanks also go to Dr. Christopher K. Mathews

Cytokinin biosynthesis in crown gall tumors

Creator:: Akiyoshi, Donna E.
Abstract:: Using combined HPLC-RIA, cytokinin levels in a series of tobacco crown gall tumors, having altered morphologies as a result of transposon mutagenesis were examined. Average trans-ribosylzeatin levels in the shoot-producing tumors (tms mutants) and root-producing tumors (tmr mutants) were 1400 pmol/gm and 0.97 pmol/gm, respectively. Cytokinin/auxin ratios were highest in...
Resource Type:: Dissertation

Modeling protein structure at atomic resolution

Creator:: Berkholz, Donald S.
Abstract:: This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...
Resource Type:: Dissertation
Full Text:: . Science 246, 1149-1152. Moffat, K., and Ren, Z. (1997). Synchrotron radiation applications to

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

Creator:: Jensen, Ole Norregaard
Abstract:: A novel protocol for the study of protein-nucleic acid interactions is presented and demonstrated to be feasible. The protocol combines photochemical crosslinking techniques and mass spectrometric methods into a new strategy for identifying protein domains or amino acid residues that are in close contact with nucleic acid in protein-nucleic acid...
Resource Type:: Dissertation
Full Text:: of Oregon) Mr. Stephen Swenson and Professor Steven Seifried (University of Hawaii) Mr. Samuel

The effect of cytosine methylation on DNA structure

Creator:: Vargason, Jeffrey M.
Abstract:: DNA methylation is common in prokaryotes and eukaryotes and has been implicated in various biological roles including gene silencing, X-chromosome inactivation, and genomic imprinting. 5-methylcytosine the "fifth base" of the genetic code comprises 1-3% of the human genome and is primarily found on cytosines within the context of the CpG...
Resource Type:: Dissertation
Full Text:: Acknowledgments We thank B. H. M. Mooers and the P. A. Karplus' laboratory for helpful discussion, and K. E. van

Regulation of expression of four baculovirus genes and the immunocytochemical characterization of their products

Creator:: Gross, Christian Hans
Abstract:: Regulation of expression of three genes in the polyhedron envelope protein (PEP) gene region of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus (OpMNPV) was examined. These genes include open reading frame (ORF) 1 (encoding p21), ORF 2 (encoding gp16), and ORF 3 (encoding the polyhedron envelope protein). The effect of...
Resource Type:: Dissertation
Full Text:: , with the rings aligned perpendicular to the longitudinal axis (Burley, 1982). The nucleocapsids have

Exploring Protein Structure: Seeing the Forest and the Trees

Creator:: Brereton, Andrew E.
Abstract:: Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...
Resource Type:: Dissertation

ScholarsArchive@OSU

Structural investigations to understand the mechanisms of two proteins involved in sulfur chemistry : SsuE and cysteine dioxygenase

Analysis of secondary structures in nucleic acid binding proteins and nuclear magnetic resonance investigation of helix propagation and residual motions in proteins

The mechanism of interaction of the linker histone with DNA and nucleosomes

Cytokinin biosynthesis in crown gall tumors

Modeling protein structure at atomic resolution

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

The effect of cytosine methylation on DNA structure

Regulation of expression of four baculovirus genes and the immunocytochemical characterization of their products

Exploring Protein Structure: Seeing the Forest and the Trees

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