Index Catalog // ScholarsArchive@OSU

In vivo detoxification of acetic acid in Saccharomyces cerevisiae

Creator:: Ding, Jun
Abstract:: The studies described in this thesis were motivated by ongoing efforts to develop lignocellulosic biomass as an efficient and practical source of renewable energy. Enormous problems complicate these efforts to reduce reliance on greenhouse gas-generating fossil fuels. Simply obtaining the fermentable sugars available in the cellulose and hemicellulose components of...
Resource Type:: Dissertation
Full Text:: Microsoft Word - Jun Ding Ph.D. Thesis 6-18-14.docx AN

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Creator:: Stoner, Christopher S.
Abstract:: Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...
Resource Type:: Dissertation
Full Text:: conditions [Ding et al., 1996]. Transcriptional activity of SoxR is only apparent once iron-sulfur centers

Functional analysis of novel β-catenin mutants

Creator:: Al-Fageeh, Mohamed B.
Abstract:: β-catenin is a multi functional protein that is involved in cell-cell adhesion and cell signaling. In non-stimulated cells, β-catenin is tightly down-regulated by GSK-3β-dependent phosphorylation at Ser and Thr residues, followed by rapid ubiquitination and proteasomal degradation. It is well established that mutations within the regulatory GSK-3β region lead to...
Resource Type:: Masters Thesis
Full Text:: ........................................................................................................... 80 22: Effects of 13-catenin over-expression on c-jun activation

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Creator:: Golonzhka, Olga
Abstract:: CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...
Resource Type:: Dissertation

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:: Li, Chuan
Abstract:: Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
Resource Type:: Dissertation
Full Text:: protein kinase C (PKC) [Patel 2008][ Huang 2002] [Bloom 2003], c-Jun N-terminal kinase (JNK), p38 MAP

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

Creator:: Fey, Rosalyn M.
Abstract:: Systems biology is a powerful approach which considers and sheds light on all of the puzzle pieces which make up complex biological processes, and is an effective alternative to unraveling these processes using traditional molecular approaches alone. It is a natural companion approach for computational biology, which leverages the power...
Resource Type:: Dissertation
Full Text:: Lasher, Patrick Morar, Lillian Padgitt-Cobb, Joseph Valencia, Nathan Waugh, Jun Yang and others. Thank

Use of γ-Glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial dysfunction, and cell death

Creator:: Will, Yvonne
Resource Type:: Dissertation

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation
Full Text:: ). Increases in ceramide levels also induce PKCthe Jun-N-terminal kinases (JNKs), lysosomal cathepsin D

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

Creator:: Narayanappa, Murugesh
Abstract:: Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost...
Resource Type:: Dissertation

ScholarsArchive@OSU

In vivo detoxification of acetic acid in Saccharomyces cerevisiae

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Functional analysis of novel β-catenin mutants

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

Use of γ-Glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial dysfunction, and cell death

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

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