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Filtering by: Creator Lee, Jai-hyo Remove constraint Creator: Lee, Jai-hyo Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • Cytoskeletal regulation in cell motility and invasion

    Creator:
    Jang, Hyo Sang
    Abstract:
    Cell motility and invasion are important for development, immunity, wound healing, and tumor cell metastasis. Cells on two dimensional substrates migrate in three steps: protrusion of the front end, translocation of the cell body, and retraction of the rear end. For cells to migrate efficiently, these steps need to be...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Hyo Sang Jang for the degree of Doctor of Philosophy in

  • Defining the Role of Tyrosine Nitration in Biology with Genetic Code Expansion

    Creator:
    Porter, Joseph J.
    Abstract:
    The buildup of reactive oxygen species (ROS) and reactive nitrogen and oxygen species (RNS) is known as oxidative stress. Oxidative stress results in a wide variety of modification to biological macromolecules including nucleic acids, lipids, and proteins. For at least 30 years it has been known that high levels of...
    Resource Type:
    Dissertation
    Full Text:
    gratitude to Hyo Sang Jang for his tireless work on covering everything I need on the eukaryotic cell

  • In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

    Creator:
    Blizzard, Robert J.
    Abstract:
    The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
    Resource Type:
    Dissertation
    Full Text:
    both Subhashis Jana and Hyo Sang Jang for their expertise in chemical synthesis and eukaryotic cell

  • Analysis of Cancer Progression by Establishing Quantitative Assessments of Zebrafish Xenografts

    Creator:
    Gamble, John T.
    Abstract:
    The goal of this dissertation was to improve our abilities in acquiring critical in vivo data by establishing embryo-larva zebrafish as an exemplary model to quantitatively evaluate cancer progression. The living environment that encompasses a tumor has a significant effect on how cancer develops, grows and metastasizes. In order to...
    Resource Type:
    Dissertation
    Full Text:
    members Hyo Sang Jang, Martin Pearce, Jessica Phillips, Bach Nguyen, Veronica Puig Sanvicens, Daniel

  • Calpain 2 proteolysis regulates glioblastoma cell invasion

    Creator:
    Lal, Sangeet Kumar
    Abstract:
    Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
    Resource Type:
    Dissertation
    Full Text:
    care. I would like to thank Hyo Sang Jang, my peer graduate student in the lab, for your friendship

  • Protein methylation at sites of blood vessel injury

    Creator:
    Weber, Darin J.
    Abstract:
    Blood vessel injury was found to release intracellular pools of protein D-aspartyl/L-isoaspartyl carboxyl methyltransferase (PIMT) into the extracellular milieu, where it became trapped. Trapped PIMT was able to utilize radiolabeled S-adenosyl-L-methionine (AdoMet) introduced into the circulation to methylate blood vessel proteins containing altered aspartyl residues specifically at the site of...
    Resource Type:
    Dissertation