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Filtering by: Advisor McFadden, Philip N. Remove constraint Advisor: McFadden, Philip N. Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • Automethylation : a response to enzyme aging

    Creator:
    Lindquist, Jonathan A.
    Abstract:
    This is the first study to explore the ability of an enzyme to recognize and repair spontaneous age-dependent damage to its own sequence. Protein (D-aspartyl/L-isoaspartyl) carboxyl methyltransferase (PCM) is known to repair damage that arises from a spontaneous isomerization of aspartyl and asparaginyl residues in other proteins during aging. As...
    Resource Type:
    Dissertation
    Full Text:
    approved: Philip N. McFadden This is the first study to explore the ability ofan enzyme to recognize

  • Biologically inspired biosensors from fish chromatophores

    Creator:
    Young, Jun
    Abstract:
    This thesis explores the feasibility of using melanophore-based biosensors from Oreochromis niloticus. Melanophores are one type of pigmented cell of the scales and fins of fish that respond in a motile fashion to a diverse range of stimuli. Fish scales were employed as the first step in determining the utility...
    Resource Type:
    Masters Thesis
    Full Text:
    Chromatophores Abstract approved: Philip N. McFadden This thesis explores the feasibility of using melanophore

  • Protein methylation at sites of blood vessel injury

    Creator:
    Weber, Darin J.
    Abstract:
    Blood vessel injury was found to release intracellular pools of protein D-aspartyl/L-isoaspartyl carboxyl methyltransferase (PIMT) into the extracellular milieu, where it became trapped. Trapped PIMT was able to utilize radiolabeled S-adenosyl-L-methionine (AdoMet) introduced into the circulation to methylate blood vessel proteins containing altered aspartyl residues specifically at the site of...
    Resource Type:
    Dissertation
    Full Text:
    Methylation at Sites of Blood Vessel Injury. Abstract approved: Philip N. McFadden Blood vessel injury was

  • Incorporation of chromatophores into multi-cellular biosensors

    Creator:
    Preston, R. Ryan
    Abstract:
    Methodologies that detect biologically active substances have important potential applications for medical diagnostics, drug discovery, and chemical and biological anti-terrorism efforts. The wide spectrum of potential analytes that induce a physiological response dictates that novel techniques be developed to more rapidly screen and characterize agents that are more economical and...
    Resource Type:
    Dissertation
    Full Text:
    : Incorporation of Chromatophores into Multi-Cellular Biosensors. Abstract approved: Philip N. McFadden