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Filtering by: Creator Pennington-Lehman, Heather Remove constraint Creator: Pennington-Lehman, Heather Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • Employing Genetic Code Expansion Tools to Elucidate Disease Mechanisms and Generate New Therapeutics

    Creator:
    Van Fossen, Elise M.
    Abstract:
    In biology, function and disease are closely intertwined, requiring the coordination of hundreds of intricate chemical reactions. Interdisciplinary cooperation between chemical and biological approaches is necessary to decipher the chemical links between physiological and pathological conditions. In this arena, the precision tools made possible with chemical biology can manipulate and...
    Resource Type:
    Dissertation
    Full Text:
    treasure your friendship forever. An especial thank you to Heather, Margaux, Shauna, Kasie and Savanna

  • Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

    Creator:
    Baker, Kasie J.
    Abstract:
    The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
    Resource Type:
    Dissertation
    Full Text:
    , Heather, and Elise. Grad school has been a wild ride but I couldn’t have asked for a better group of

  • Defining the Role of Tyrosine Nitration in Biology with Genetic Code Expansion

    Creator:
    Porter, Joseph J.
    Abstract:
    The buildup of reactive oxygen species (ROS) and reactive nitrogen and oxygen species (RNS) is known as oxidative stress. Oxidative stress results in a wide variety of modification to biological macromolecules including nucleic acids, lipids, and proteins. For at least 30 years it has been known that high levels of...
    Resource Type:
    Dissertation
    Full Text:
    (and Alexa), James, Shauna, Ally, Nathan, Heather, Elise, Amber, Kayla, Ruben, and Phil. You’ve all