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Filtering by: Subject Thiols Remove constraint Subject: Thiols Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • Mitochondrial glutathione and the effect of perturbed calcium homeostasis on rat hepatocyte thiols

    Creator:
    Olafsdottir, Kristin
    Abstract:
    Recent studies have demonstrated that perturbations of intracellular thiol and calcium homeostasis may be important events in the early development of cell injury by toxic chemicals. Incubation of isolated rat hepatocytes in a calcium free medium, severely depleted intracellular Ca²⁺ levels and resulted in the loss of both cytosolic and...
    Resource Type:
    Dissertation
    Full Text:
    intracellular thiol and calcium homeostasis may be important events in the early development of cell injury by

  • Dietary organosulfur and organoselenium compounds as HDAC inhibitors

    Creator:
    Nian, Hui
    Abstract:
    Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
    Resource Type:
    Dissertation