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Filtering by: Academic Affiliation Clinical Sciences Creator Marley, Kevin

Dasatinib Modulates Invasive and Migratory Properties of Canine Osteosarcoma and has Therapeutic Potential in Affected Dogs

Creator:

Marley, Kevin, Gullaba, Justine, Seguin, Bernard, Gelberg, Howard B., and Helfand, Stuart C.

Abstract:

BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evidence of an apparent clinical benefit from adjuvant therapy with dasatinib in four dogs is described. METHODS: The inhibitors were assessed...

Resource Type:

Article