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Filtering by: Committee Member Edge, W. Daniel Academic Affiliation College of Pharmacy

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Creator:

Watanalumlerd, Prapoch

Abstract:

Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...

Resource Type:

Dissertation

Full Text:

thank Dr. Daniel W. Schafer of the Department of Statistics and Dr. Thomas F. Savage of the Department
The study of pharmacokinetics in a clinical environment

Creator:

Tse, Sunny

Abstract:

This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...

Resource Type:

Dissertation

Full Text:

. Abstract approved: James W. Ayres This dissertation presents a research series