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Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Creator:: Wierzbicki, Igor H.
Abstract:: The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Resource Type:: Dissertation
Full Text:: . ©Copyright by Igor H. Wierzbicki September 28, 2016 All Rights Reserved Characterization and

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...
Resource Type:: Article

Polymeric Micelles as Carriers for Nerve-Highlighting Fluorescent Probe Delivery

Creator:: Hackman, Kayla M., Doddapaneni, Bhuvana Shyam, Barth, Connor W., Wierzbicki, Igor H., Alani, Adam W. G., and Gibbs, Summer L.
Abstract:: ACS Editors' Choice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Resource Type:: Article

Metabolomic Profiling of Natural Products from Two Tolypocladium Fungal Species as Part of An Evolutionary Genomics Study

Creator:: Dickey, Bailey J.
Abstract:: This thesis describes an investigation of the natural products chemistry of two fungal species of the genus Tolypocladium. Natural products are small organic molecules that are considered non-essential for cell growth and reproduction, and thus part of secondary metabolism. Chemical profiling of these secondary metabolites using a combination of high-performance...
Resource Type:: Masters Thesis
Full Text:: Neisseria gonorrhoeae growth inhibitory assay contributed from Dr. Alexandra Sikora and Igor Wierzbicki

Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

Creator:: Baarda, Benjamin I.
Abstract:: Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
Resource Type:: Dissertation

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Creator:: Doddapaneni, Bhuvana S.
Abstract:: Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
Resource Type:: Dissertation
Full Text:: are both listed as equal contributors to this project. Igor helped with the cell work. Kayla and

Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

Creator:: Vining, Oliver B.
Abstract:: Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
Resource Type:: Dissertation
Full Text:: microorganisms in laboratory culture. Igor Wierzbicki and Nini Tran performed biological assays to evaluate

Nanotheraputic Platforms to address Chemotherapeutic Challenges in Breast and Ovarian Cancer Treatment

Creator:: Al Fatease, Adel
Abstract:: Utilizing nanocarrier based drug delivery for improving the magnitude of efficacy of chemotherapeutic agents in many diseases has acquired more attention in research applications. It has shown promising results in both preclinical and clinical trials. The Food and Drug Administration (FDA) has approved many of these polymeric carriers, and tens...
Resource Type:: Dissertation
Full Text:: 3.5 SERUM CONCENTRATION OF CTN-1 LEVELS IN HEALTHY SWISS WEBSTER MICE COLLECTED WITHIN 24 H AFTER

Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

Creator:: Nguyen, Duc X.
Abstract:: TAC is the most commonly used medication in post transplantation maintenance immunosuppression therapy. TAC lipophilicity and its erratic oral absorption especially in the presence of food intake result in great intra- and interpatient pharmacokinetic variations. Complicated dosing and frequent required therapeutic monitoring is thought to be the main cause of...
Resource Type:: Dissertation
Full Text:: -patient variation in elimination half-life, 124 h in children, and 2.1-36 h in adult transplant

Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin, Preparation of orally disintegrating tablets of melatonin and acetaminophen, Pharmacokinetics of terbinafine in penguins

Creator:: Le, Hang Thi
Abstract:: The first project of this thesis is an in vitro study. This study was performed with 8 hydrocortisone topical products on the market for the purpose of comparing one Tec Lab product, a Corticool gel, to the other seven common products on the market. The permeation of these products was...
Resource Type:: Dissertation
Full Text:: permeation through both the mouse skin and the EpiDermTM (2.24±0.38% vs. 0.68 ± 0.20% in 24 h with

ScholarsArchive@OSU

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target

Polymeric Micelles as Carriers for Nerve-Highlighting Fluorescent Probe Delivery

Metabolomic Profiling of Natural Products from Two Tolypocladium Fungal Species as Part of An Evolutionary Genomics Study

Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

Nanotheraputic Platforms to address Chemotherapeutic Challenges in Breast and Ovarian Cancer Treatment

Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin, Preparation of orally disintegrating tablets of melatonin and acetaminophen, Pharmacokinetics of terbinafine in penguins

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