Index Catalog // ScholarsArchive@OSU

Comparison of pressurized liquid extraction and matrix solid phase dispersion for the measurement of semi-volatile organic compound accumulation in tadpoles

Creator:: Stanley, Kerri, Simonich, Staci Massey, Bradford, David, Davidson, Carlos, and Tallent-Halsell, Nita
Abstract:: Analytical methods capable of trace measurement of semi-volatile organic compounds (SOCs) are necessary to assess the exposure of tadpoles to contaminants as a result of long-range and regional atmospheric transport and deposition. The following study compares the results of two analytical methods, one using pressurized liquid extraction (PLE) and the...
Resource Type:: Article

Temporal and spatial variation of atmospherically deposited organic contaminants at high elevation in Yosemite National Park, California, USA

Creator:: Bradford, David F., Stanley, Kerri A., Tallent, Nita G., Sparling, Donald W., Nash, Maliha S., Knapp, Roland A., McConnell, Laura L., and Simonich, Staci L. Massey
Abstract:: Contaminants used at low elevation, such as pesticides on crops, can be transported tens of kilometers and deposited in adjacent mountains in many parts of the world. Atmospherically deposited organic contaminants in the Sierra Nevada Mountains of California, USA, have exceeded some thresholds of concern, but the spatial and temporal...
Resource Type:: Article
Full Text:: David F. Bradford 4 U.S. Environmental Protection Agency 5 National Exposure Research Laboratory 6

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ David E. Williams The objective of this work is to add to the body of

Flavin-containing monooxygenase : metabolism and toxicity of anti-tuberculosis drug ethionamide in lung

Creator:: Singh, Priti B.
Abstract:: Multiple drug resistance (MDR) Tuberculosis (TB), leads to increased use of “second-line” drugs; one of the most effective is ethionamide (ETA). ETA is a prodrug metabolized by a mycobacterial flavin-containing monooxygenase (EtaA) as well human flavin-containing monooxygenases (FMOs). Of the five functional FMOs of humans, FMOs 1, 2, and 3...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: David E. Williams Multiple drug resistance (MDR) Tuberculosis (TB

Physiological and organism level endpoints in the beetle pterostichus oblongopunctatus (Coleoptera: Carabidae), inhabiting a gradient of heavy metal pollution

Creator:: Stone, David
Abstract:: Pollutant body burdens, ability to tolerate supplementary stressors, and biomarkers of physiological stress were investigated in the ground beetle, Pterostichus oblongopunctatus (Coleoptera: Carabidae), inhabiting a gradient of heavy metal contamination in Poland. The central question was to determine if beetles inhabiting polluted habitats incurred costs compared with beetles in less...
Resource Type:: Dissertation
Full Text:: An Abstract of the Dissertation of David L. Stone for the

Respiratory strategies and associated exchange epithelia as determinants on contaminant uptake in aquatic insects

Creator:: Buchwalter, David B.
Abstract:: Aquatic insects are used extensively to evaluate water quality. Despite their widespread use as indicator organisms, relatively little is known about the organismal characteristics that determine sensitivity differences to individual and multiple stressors. Insects have evolved several respiratory strategies that range from breathing atmospheric air to utilizing dissolved oxygen in...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF David B. Buchwalter for the

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Creator:: Rosemond, Marie Victoire M.
Abstract:: Previous studies have shown that rainbow trout exposed to dieldrin via diet for 9 to 12 weeks increased biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500%. This was not explained by induction of the cytochrome P-450 (CYP) system involved in oxidative metabolism of these compounds. We hypothesized that...
Resource Type:: Masters Thesis
Full Text:: appreciation to the members of my graduate committee for their input and participation: Dr. David E. Williams

Biochemical and physiological indicators of behavioral impairment in salmonids exposed to chlorpyrifos and copper

Creator:: Sandahl, Jason
Abstract:: The purpose of this work was to determine if environmentally-relevant concentrations of chlorpyrifos and copper, two commonly detected chemicals in Western surface waters, can negatively impact the biological health of salmonids. Both compounds are highly neurotoxic to fish, but each with distinct biological target sites and mechanisms of action. We...
Resource Type:: Dissertation
Full Text:: support provided by David Baldwin and Jana Labenia, much of this work would not have been possible. I

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Creator:: Kaetzel, Rhonda Sue
Abstract:: Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...
Resource Type:: Dissertation
Full Text:: Buhier, BaIz Frei, Jean Hall, and David Williams, for their willingness and critical evaluation of my

Dieldrin stimulates biliary excretion of [14 C] benzo[a]pyrene polar metabolites but does not change the metabolite profile in rainbow trout (Oncorhyncus mykiss)

Creator:: Barnhill, Melanie L.
Abstract:: Feeding rainbow trout 0.3-0.4 mg dieldrinlkg/d for 9-12 weeks stimulated the biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500% and [³H]7,12- dimethylbenz[a]anthracene (DMBA) by 240%. In vitro work demonstrated that this interaction occurred without induction of the cytochrome P450 system, or other hepatocellular proteins involved in metabolism. The...
Resource Type:: Masters Thesis
Full Text:: . William M. Baird, Dr. Philip Whanger, Rob Chitwood, Sam Bradford, Corwin Willard, Tamara Musafija-Jeknic

ScholarsArchive@OSU

Comparison of pressurized liquid extraction and matrix solid phase dispersion for the measurement of semi-volatile organic compound accumulation in tadpoles

Temporal and spatial variation of atmospherically deposited organic contaminants at high elevation in Yosemite National Park, California, USA

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Flavin-containing monooxygenase : metabolism and toxicity of anti-tuberculosis drug ethionamide in lung

Physiological and organism level endpoints in the beetle pterostichus oblongopunctatus (Coleoptera: Carabidae), inhabiting a gradient of heavy metal pollution

Respiratory strategies and associated exchange epithelia as determinants on contaminant uptake in aquatic insects

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Biochemical and physiological indicators of behavioral impairment in salmonids exposed to chlorpyrifos and copper

A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Dieldrin stimulates biliary excretion of [14 C] benzo[a]pyrene polar metabolites but does not change the metabolite profile in rainbow trout (Oncorhyncus mykiss)

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