Index Catalog // ScholarsArchive@OSU

Assessing the toxicity of nanoplastics using the primary human bronchial epithelial model

Creator:: Germano, Francesca
Abstract:: Emerging data showing the presence of atmospheric microplastics (MPs) has recently raised awareness surrounding the potential of human nanoplastics (NPs) exposure. Due to factors such as weathering, UV exposure, and other biodegradation processes, plastic pollution in the environment breaks down over time into micro (<5 micrometers) and nanoscale (<1000nm) particles....
Resource Type:: Masters Thesis
Full Text:: nanospheres which were purchased as 0.19µm beads provided at 2.5% solids (w/v) aqueous solution from

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Creator:: Rohlman, Diana
Abstract:: The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Diana Rohlman

Exploring Silicone Wristbands as Personal Passive Sampling Devices in a Disaster Scenario

Creator:: Samon, Samantha M.
Abstract:: Exposure assessment is necessary to determine the frequency and magnitude of environmental contaminants, especially since exposure may lead to adverse health outcomes. Traditional personal exposure assessment tools such as biological samples are limited in their ability to capture a wide range of chemical exposures from a single sample, and others...
Resource Type:: Dissertation
Full Text:: graduate committee members Dr. Diana Rohlman, Dr. Craig Marcus, Dr. Dave Williams, and Dr. Molly Kile

Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

Creator:: Wilson, Lindsay B.
Abstract:: The field of toxicology is challenged with a vast number of environmental chemicals and mixtures to which humans and ecosystems are exposed with limited toxicity data available. Chemical hazard assessment traditionally utilizes mammalian models and can be both cost- and time-limiting and may pose ethical concerns. To rapidly tackle this...
Resource Type:: Dissertation
Full Text:: – Mary Mucia, Cheyenne Pozar, Drs. Susan Tilton, Kim Anderson, Diana Rohlman, Molly Kile, Craig Marcus

Assessing Exposures and Simplifying Complex Mixtures of SVOCs for Hazard Characterization using Alternative Model Systems

Creator:: Rivera, Brianna N.
Abstract:: Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...
Resource Type:: Dissertation
Full Text:: . .............................................................................................. 52 Figure 3.3. Chemical Composition of Surrogate Mixtures Chemicals greater than 3% v/v in the

Assessing Chemical Dispersants Used During the Deepwater Horizon Oil Spill : Method Innovation and Application

Creator:: Perkins, Matt J.
Abstract:: Large quantities of the chemical oil dispersant Corexit were applied in the Gulf of Mexico (Gulf) in response to the Deepwater Horizon oil spill. Large data gaps regarding the potential transport, persistence and impact of Corexit in the Gulf existed at the time of the emergency response. Analytical methods for...
Resource Type:: Dissertation
Full Text:: . V.; Baums, I. B.; Cordes, E. E., Response of deep-water corals to oil and chemical dispersant

Continuous monitoring and modeling to assess pesticide exposure in critical habitat for Pacific salmonids

Creator:: Janney, Philip K.
Abstract:: Pacific Northwest and California freshwater resources are key elements in the life history and ecology of Pacific salmon and steelhead listed as threatened or endangered under the Endangered Species Act. Risk to listed Pacific salmonid species can be assessed by evaluating the spatial and temporal co-occurrence of salmonid species at...
Resource Type:: Dissertation

Applications of Silicone Wristbands to Improve Personal Chemical Exposure Assessment

Creator:: Dixon, Holly M.
Abstract:: Silicone wristbands are easy-to-wear passive samplers that have been readily adapted into environmental health studies since first reported in 2014. Wristbands can be worn during normal daily activities and sequester a wide range of bioavailable organic chemicals. This dissertation includes a thorough review of silicone wristband technology, as well as...
Resource Type:: Dissertation
Full Text:: like to thank Dr. Steven O’Connell, Dr. Diana Rohlman, Ricky Scott, Dr. Blair Paulik, Dr. Carey

New applications and emerging contaminants : developing silicone passive sampling devices for environmental and novel monitoring applications

Creator:: O'Connell, Steven G.
Abstract:: Passive sampling is a popular technology for environmental monitoring, and silicone is an ideal choice for a variety of passive sampling applications. The silicone work described here encompasses laboratory and field studies that demonstrate the use of this polymer in novel environments, for new applications, and for emerging compounds. Unique...
Resource Type:: Dissertation
Full Text:: and not just so they look nice. In a separate category all by herself is my wife Diana. She

Characterization of rodent selenoprotein W promoter

Creator:: Amantana, Adams
Abstract:: Rat selenoprotein W (SeW) promoter activity was investigated using different concentrations of cadmium, copper, and zinc. Two fragments (404bp and 1265bp) of the SeW promoter, containing a single metal response element (MRE), were ligated into the multiple cloning site of a pGL3-Basic reporter plasmid. The constructs were transfected into cultured...
Resource Type:: Dissertation
Full Text:: to remain a part of this sterling family. I am most grateful to Diana Wilson, my sister-in-law, for

ScholarsArchive@OSU

Assessing the toxicity of nanoplastics using the primary human bronchial epithelial model

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Exploring Silicone Wristbands as Personal Passive Sampling Devices in a Disaster Scenario

Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

Assessing Exposures and Simplifying Complex Mixtures of SVOCs for Hazard Characterization using Alternative Model Systems

Assessing Chemical Dispersants Used During the Deepwater Horizon Oil Spill : Method Innovation and Application

Continuous monitoring and modeling to assess pesticide exposure in critical habitat for Pacific salmonids

Applications of Silicone Wristbands to Improve Personal Chemical Exposure Assessment

New applications and emerging contaminants : developing silicone passive sampling devices for environmental and novel monitoring applications

Characterization of rodent selenoprotein W promoter

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