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Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei

Creator:

Jacobs, Dakota

Abstract:

Ovulation requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from preoptic hypothalamic neurons, initiated by elevated ovarian estradiol (E₂). Rising estradiol activates a subset of sexually dimorphic kisspeptin (Kiss-1) neurons in the female, located in the anteroventral periventricular nuclei (AVPV). Conversely, estradiol negative feedback on GnRH secretion is mediated by a...

Resource Type:

Masters Thesis

Full Text:

hormone (GnRH) from preoptic hypothalamic neurons, initiated by elevated ovarian estradiol (E2). Rising