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Filtering by: Advisor Goulding, Robert L. Remove constraint Advisor: Goulding, Robert L. Academic Affiliation Environmental and Molecular Toxicology Remove constraint Academic Affiliation: Environmental and Molecular Toxicology

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  • Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

    Creator:
    Garland, Michael A.
    Abstract:
    Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
    Resource Type:
    Dissertation
    Full Text:
    : _____________________________________________________________________ Robert L. Tanguay Zebrafish are capable of fully regenerating organs and tissue such as

  • Nanoparticle features and their relative influence on biological responses

    Creator:
    Denluck, Lindsay
    Abstract:
    Nanoparticles (NPs), defined as materials having at least one dimension (height, width, diameter) in the nanoscale, are increasingly being incorporated into a wide variety of products and are replacing traditional bulk materials in many applications. This is because they can be more efficacious, more sustainable, and can have unique characteristics...
    Resource Type:
    Dissertation
    Full Text:
    Features and their Relative Influence on Biological Responses Abstract approved: Robert L. Tanguay

  • Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

    Creator:
    Holden, Laura, L.
    Abstract:
    Since 2007, electronic cigarette (e-cigarette) sales in the U.S. have surpassed those of tobacco cigarettes. This is due, in part, to manufacturer’s claims that they are a safer alternative to tobacco cigarettes. However, formaldehyde, acrolein, and diacetyl have been detected in e-cigarettes and public knowledge of e-cigarette composition and potential...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: ______________________________________________________ Robert L. Tanguay Since 2007

  • Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

    Creator:
    Geier, Mitra Celestine
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
    Resource Type:
    Dissertation
    Full Text:
    Robert L. Tanguay Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants

  • Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

    Creator:
    Haggard, Derik
    Abstract:
    There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________ Robert L. Tanguay There are more than 87,000 chemicals in current use with little to no

  • Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

    Creator:
    Goodale, Britton C.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
    Resource Type:
    Dissertation
    Full Text:
    :___________________________________________________________________________________ Robert L. Tanguay Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the

  • Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

    Creator:
    Saili, Katerine Schletz
    Abstract:
    Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
    Resource Type:
    Dissertation
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    approved: _____________________________________________________ Robert L. Tanguay Billions of pounds of

  • Developing rapid in vivo assays to investigate structure response relationships

    Creator:
    Truong, Lisa
    Abstract:
    Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________ Robert L. Tanguay Incorporation of nanoparticles (NPs) into consumer products is on the rise

  • Developmental ramifications of dithiocarbamate pesticide exposure in zebrafish

    Creator:
    Tilton, Fred Anthony, 1973-
    Abstract:
    Dithiocarbamates are widely used agricultural pesticides, industrial chemicals and effluent additives. DTCs and their related compounds have historical and current relevance in clinical and experimental medicine. DTC developmental toxicity is well established, but poorly understood. Dithiocarbamates according to the U.S. EPA have a mechanism of action involving, "the inhibition of...
    Resource Type:
    Dissertation
    Full Text:
    #10257 and funds from the Robert L. Tanguay Laboratory. Others I would like to acknowledge are The

  • Chemical and biological approaches to identify vertebrate tissue regeneration pathways

    Creator:
    Sengupta, Sumitra
    Abstract:
    Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
    Resource Type:
    Dissertation
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    Robert L. Tanguay Abstract Numerous human conditions would be improved if therapies to encourage