Index Catalog // ScholarsArchive@OSU

Consequences of miRNA misregulation on embryonic development and aging

Creator:: Franzosa, Jill A.
Abstract:: microRNAs (miRNAs), ~21-24 nucleotide-long RNAs that post-transcriptionally regulate gene expression, have rapidly become one of the most extensively studied mechanisms of the past decade. Since their discovery as temporal regulators of post-embryonic development in C. elegans, miRNAs have been functionally implicated in almost every cellular process investigated to date. miRNAs...
Resource Type:: Dissertation
Full Text:: Kim, Dr. Sean Bugel, Joe Fisher, Leah Wehmas, Andrea Knecht, Carrie Barton, Hao Truong, Chapel

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: and support: Chapell Miller, Greg Gonnerman, Eric Johnson, Michael Simonich, and Carrie Barton. Lisa

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

Creator:: Holden, Laura, L.
Abstract:: Since 2007, electronic cigarette (e-cigarette) sales in the U.S. have surpassed those of tobacco cigarettes. This is due, in part, to manufacturer’s claims that they are a safer alternative to tobacco cigarettes. However, formaldehyde, acrolein, and diacetyl have been detected in e-cigarettes and public knowledge of e-cigarette composition and potential...
Resource Type:: Masters Thesis
Full Text:: , I have had many mentors in his lab, including but not limited to: Carrie Barton, Dr. Lisa Truong

Developing rapid in vivo assays to investigate structure response relationships

Creator:: Truong, Lisa
Abstract:: Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
Resource Type:: Dissertation
Full Text:: greatly appreciated and will be remembered forever. Eric Johnson has to be thanked for helping make

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: morpholino injections and maintenance of the transgenic zebrafish lines, Carrie Barton for managing the

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Creator:: Axton, Elizabeth R.
Abstract:: Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
Resource Type:: Dissertation

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Creator:: Saili, Katerine Schletz
Abstract:: Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
Resource Type:: Dissertation

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Creator:: Geier, Mitra Celestine
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Resource Type:: Dissertation
Full Text:: Team for their help loading and screening plates, Carrie Barton and Eric Johnson for keeping the fish

Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

Creator:: Wilson, Lindsay B.
Abstract:: The field of toxicology is challenged with a vast number of environmental chemicals and mixtures to which humans and ecosystems are exposed with limited toxicity data available. Chemical hazard assessment traditionally utilizes mammalian models and can be both cost- and time-limiting and may pose ethical concerns. To rapidly tackle this...
Resource Type:: Dissertation
Full Text:: here. Eric Johnson, Carrie Barton, John Lam, Josh White, you have been so helpful around the lab and

Advancement of Passive Sampling Applications for Assessing Contaminant Transport, Bioaccumulation, and Toxicity

Creator:: Minick, David J.
Abstract:: In the environment, it is the unbound fraction of chemical (Cfree) which is able to diffuse across environmental interfaces and biological membranes. It is therefore Cfree which drives many important biological-environmental processes including contaminant transport, bioaccumulation and toxicity. Passive sampling devices (PSDs) offer a simplified and more accurate approach for...
Resource Type:: Dissertation

ScholarsArchive@OSU

Consequences of miRNA misregulation on embryonic development and aging

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

Developing rapid in vivo assays to investigate structure response relationships

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

Advancement of Passive Sampling Applications for Assessing Contaminant Transport, Bioaccumulation, and Toxicity

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