Index Catalog // ScholarsArchive@OSU

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

Creator:: Yu, Zhen
Abstract:: The antimutagenic potency of wheat grain and berry extracts was studied in vitro against several heterocyclic amines (HCAs) using the Salmonella mutagenicity assay and the anticarcinogencity of wheat grain was studied in vivo using the rat colonic aberrant crypt focus assay. Wheat bran, which binds HCAs in vitro, as well...
Resource Type:: Masters Thesis
Full Text:: Privacy ACKNOWLEDGEMENT S I would like to express my sincerest gratitude to Dr. David E. Williams and

Factors contributing to the formation of CC-->TT tandem mutations

Creator:: Skinner, Amy M.
Abstract:: The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Resource Type:: Dissertation
Full Text:: and antioxidants offered by Dr. Roderick Dashwood. I am also thankful for the support and advice

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Creator:: Smith-Roe, Stephanie L.
Abstract:: The DNA mismatch repair (MMR) pathway maintains genomic stability and reduces cancer risk (colorectal and other internal cancers) by correcting polymerase errors and activating cell cycle checkpoints and apoptosis in response to DNA damage. Few studies have examined the influence of commonly encountered environmental mutagens/carcinogens on the etiology of MMR-deficient...
Resource Type:: Dissertation
Full Text:: direction to my research. I also thank my committee members Dr. Roderick Dashwood, Dr. Mitchell Turker, and

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Creator:: Yu, Zhen
Abstract:: Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Resource Type:: Dissertation
Full Text:: thank Dr. George S. Bailey, Dr. Roderick H. Dashwood, Dr. Ronald E. Wrolstad and Dr. Susan J. Tornquist

Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells

Creator:: Lee, Seong-Ho, Richardson, Raphael L., Dashwood, Roderick H., and Baek, Seung Joan
Abstract:: Capsaicin is a pungent ingredient in chili red peppers and has been linked to suppression of growth in various cancer cells. However, the underlying mechanism(s) by which capsaicin induces growth arrest and apoptosis of cancer cells is not completely understood. In the present study, we investigated whether capsaicin alters β-catenin-dependent...
Resource Type:: Article
Full Text:: -catenin in human colorectal cancer cells Seong-Ho Leea*, Raphael L. Richardsona, Roderick H

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Creator:: Shorey, Lyndsey E., Hagman, Amanda M., Williams, David E., Ho, Emily, Dashwood, Roderick H., and Benninghoff, Abby D.
Abstract:: Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...
Resource Type:: Article
Full Text:: E. Williams1,2, Emily Ho2,4, Roderick H. Dashwood1,2, Abby D. Benninghoff3,5,6* 1 Department of

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: studies. Although not on my committee, Dr. Roderick Dashwood and Dr. George Bailey also provided advice

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Creator:: Shorey, Lyndsey E.
Abstract:: Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Resource Type:: Dissertation
Full Text:: . Roderick Dashwood, for their scientific contributions and support during this chapter in my life

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: compliance. Roderick H. Dashwood and Emily Ho provided study design support. Frank J. Gonzalez generated

Characterization of rodent selenoprotein W promoter

Creator:: Amantana, Adams
Abstract:: Rat selenoprotein W (SeW) promoter activity was investigated using different concentrations of cadmium, copper, and zinc. Two fragments (404bp and 1265bp) of the SeW promoter, containing a single metal response element (MRE), were ligated into the multiple cloning site of a pGL3-Basic reporter plasmid. The constructs were transfected into cultured...
Resource Type:: Dissertation
Full Text:: statistical analysis. Mean values were compared by a one-way analysis of variance (ANOVA) with Tukey' s

ScholarsArchive@OSU

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

Factors contributing to the formation of CC-->TT tandem mutations

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Characterization of rodent selenoprotein W promoter

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