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Filtering by: Academic Affiliation Microbiology Date issued sim 2011-03

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish

Creator:

Rodriguez-Mari, Adriana, Wilson, Catherine, Titus, Tom A., Canestro, Cristian, BreMiller, Ruth A., Yan, Yi-Lin, Nanda, Indrajit, Johnston, Adam, Kanki, John P., Gray, Erin M., He, Xinjun, Spitsbergen, Jan, Schindler, Detlev, and Postlethwait, John H.

Abstract:

Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that...

Resource Type:

Article
The response to forced decompression in six species of Pacific rockfish

Creator:

Pribyl, Alena L., Kent, Michael L., Parker, Steven J., and Schreck, Carl B.

Abstract:

Pacific rockfish experience high discard mortality when captured owing to a condition called barotrauma,which is caused by the change in pressure during capture. This condition appears to be species specific at the macroscopic level; however, little is known about the microscopic tissue-level effects of barotrauma. Determining whether tissue-level injuries are...

Resource Type:

Article