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Filtering by: Academic Affiliation Zoology Creator Giebultowicz, Jadwiga M.

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Creator:

Beaver, Laura M., Klichko, Vladimir I., Chow, Eileen S., Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C., Radyuk, Svetlana N., and Giebultowicz, Jadwiga M.

Abstract:

Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...

Resource Type:

Article
Loss of circadian clock accelerates aging in neurodegeneration-prone mutants

Creator:

Krishnan, Natraj, Rakshit, Kuntol, Chow, Eileen S., Wentzell, Jill S., Kretzschmar, Doris, and Giebultowicz, Jadwiga M.

Abstract:

Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circadian rhythms are observed in many neurological diseases; however, it is not clear whether loss of rhythms is the cause or...

Resource Type:

Article