Dissolved oxygen profiles made with an in situ polarographic
device reveal structure in the form of inversions and gradient
changes in the 100-600 meter depth zone off Oregon. Inversions
10-70 meters thick are traced over distances of 40 miles in some
cases and are bracketed by a distance of 8...
The logic control system of a computer automatically sequences
logic operations which direct how and when memory stored instructions
and data are processed in the digital registers.
This thesis contains circuit schematics and test results of a
nanosecond response logic - control system for the Galaxy Computer.
The circuit designs...
This paper reviews some of the distributional features of vertically migrating micronekton off Oregon; describes a new, conducting-cable, midwater-trawl system using an eight-net, opening-closing cod-end unit; and gives some preliminary results on trawl catches relative to sound-scattering layers. A variable complex of organisms, including euphausiids, a sergestid shrimp, and mesopelagic...
The purpose of the thesis is to design, construct,
program, and test an automatic integrated circuit test
system. The class of integrated circuits tested was restricted
to digital integrated circuits. The general concept
of testing a digital integrated circuit is based on
the truth table of that circuit. A combination...
Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
β-catenin is a multi functional protein that is involved in cell-cell adhesion and cell signaling. In non-stimulated cells, β-catenin is tightly down-regulated by GSK-3β-dependent phosphorylation at Ser and Thr residues, followed by rapid ubiquitination and proteasomal degradation. It is well established that mutations within the regulatory GSK-3β region lead to...
Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
A majority of eighteenth-century novels remain in regular print over two hundred years since their inception. Yet with the possible exception of Robinson Crusoe, they have largely fallen out of popularity, rarely appearing on "The Summer's Hottest Reading" lists or receiving celebrity endorsement. I consider Ian Watt's foundational study, The...