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Filtering by: Creator Baker, Luther Galloway, Jr. Advisor Ayres, James W.

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Creator:

Ahmed, Iman Saad

Abstract:

This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...

Resource Type:

Dissertation
Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Creator:

Watanalumlerd, Prapoch

Abstract:

Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...

Resource Type:

Dissertation