Index Catalog // ScholarsArchive@OSU

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Creator:: Watanalumlerd, Prapoch
Abstract:: Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
Resource Type:: Dissertation
Full Text:: Formulations 3) Development of Leaky Enteric-Coated Pellets Formulations Abstract James W. Effects of

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: . Abstract approved: James W. Ayres This dissertation presents a research series

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Creator:: Rakkanka, Vipaporn
Abstract:: This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
Resource Type:: Dissertation
Full Text:: Oral Formulations, (3) A Novel Zero Order Release Matrix Tablet. Abstract approved James W This

Assay and pharmacokinetics of dyphylline following oral administration in humans

Creator:: Gisclon, Lee Gehl
Abstract:: Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
Resource Type:: Masters Thesis
Full Text:: ORAL ADMINISTRATION IN HUMANS Abstract approved: Redacted for privacy James W. Ayr4s(e7.D. Improved

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Creator:: Farid, Samar Farghali
Abstract:: This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
Resource Type:: Dissertation
Full Text:: Hypertensive Patients. Abstract Approved: James W This thesis describes in vitro and in vivo evaluation of a

Development and in vivo testing of a gastric retention device (GRD) in dogs

Creator:: Kapsi, Shivakumar G.
Abstract:: This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
Resource Type:: Dissertation
Full Text:: received from my Prof. James W. Ayres during my graduate studies. I consider myself privileged to have

Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits

Creator:: Mayo, Charles Edward
Abstract:: The bioavailability and pharmacokinetics of theophylline in rabbits were determined following both oral and intravenous administration of the drug. Serum theophylline concentrations were determined using high pressure liquid chromatography. Pharmacokinetic parameters were determined and verified by computer analysis. The overall mean Beta disposition constant was 0.089 hr⁻¹ which corresponds to...
Resource Type:: Masters Thesis
Full Text:: DYPHYLLINE AND THEOPHYLLINE IN RABBITS Abstract approved: Redacted for Privacy Dr. James W. Ayres V Part

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Creator:: Laskar, Paul A.
Abstract:: The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was investigated in several buffered aqueous media, in mixed solvent and in nonaqueous solvent systems, and in the presence of several electrolytes and nonelectrolytes. The degradation rate constant of BCNU in these systems was calculated from the parameters of the linear regression of...
Resource Type:: Dissertation
Full Text:: privacy Dr. James W. All The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was

Development and evaluation of a sustained release amoxicillin dosage form

Creator:: Ge, Yan, 1962-
Resource Type:: Masters Thesis
Full Text:: . James W. Ayres. Who was the instructor of my first class I took in the US. That class gave me the

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

Creator:: Lee, Beom-jin
Resource Type:: Dissertation
Full Text:: System for Melatonin in Human Sublects. Abstract approved: James W. Ayres, Melatonin (MT

ScholarsArchive@OSU

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

The study of pharmacokinetics in a clinical environment

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Assay and pharmacokinetics of dyphylline following oral administration in humans

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Development and in vivo testing of a gastric retention device (GRD) in dogs

Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Development and evaluation of a sustained release amoxicillin dosage form

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

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