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Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation

Creator:: Huston, Thomas K.
Abstract:: Dyphylline has been shown to be rapidly and completely absorbed from oral tablets in an absolute bioavailability study. In a pilot study two healthy male subjects received 1000 mg of dyphylline via intravenous infuson at a rate of 50 mg/min (1.0 ml/min) for 20 minutes. Plasma samples were collected for...
Resource Type:: Masters Thesis
Full Text:: Science Laboratories, inc., P.O. Box 440, State College, PA 16801 h Neothylline Tablets, Lemmon Pharmacal

Creator:: Keller, Carol Ann
Abstract:: Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
Resource Type:: Dissertation
Full Text:: S 1.0 1.0 1.0 1.0 1.0 F 0.88 C, (mg/L) 8.0 9.3 6.8 tmax (h) 0.5 1 0.7 0.9 t112 (h) 1.8 1.8 1.8

Creator:: Tavipatana, Wattanaporn
Abstract:: Pharmacokinetics of theophylline and N-7 substituted theophylline in rabbits when administered alone and in various combinations were investigated. This thesis has four chapters dealing with etophylline and theophylline; proxyphylline and theophylline; dyphylline and theophylline; and etophylline, proxyphylline and dyphylline pharmacokinetics when administered concomitantly. All chapters are interrelated. Each chapter has...
Resource Type:: Masters Thesis

Creator:: Panomvana, Duangchit
Resource Type:: Dissertation
Full Text:: express my sincere appreciation to Dr. J. H. Block for his guidance and helpful suggestions throughout

Creator:: Stevens, Ruth E.
Abstract:: Pharmacokinetic parameters for theophylline and dyphylline were evaluated in horse cerebrospinal fluid (csf) and plasma. Pharmacokinetic parameters did not differ significantly (p > 0.05) at the same dose for either drug when administered alone or concomitantly. Theophylline and dyphylline penetrate horse csf to produce approximately 1/2 the concentrations found in...
Resource Type:: Dissertation
Full Text:: CORRESPONDING COMPUTER DATA OUTPUT FOR INDIVIDUAL HORSES APPENDIX H: SASR STATISTICAL COMPUTER PROGRAMS 272

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