This dissertation is comprised of four distinct formulation sections, which are described below: A novel solid dosage formulation was investigated for achieving zero-order drug release profile by combining tablet shape design and tablet membrane film coating. Verapmail (model drug) was compressed into hydrophilic matrix tablet cores of flat-faced and bi-convex...
A high-pressure liquid chromatography method based on
reported literature was developed for the quantitative
analysis of chlorpheniramine, pseudoephedrine,
phenylpropanolamine and acetaminophen in dissolution
fluids and urine. The effects of buffer, pH and different
concentrations of organic solvent in the mobile phase on
chromatographic separation are described in Chapter I.
Dissolution...
Development of a novel, useful, orally administered dosage form
providing controlled, sustained release of an active ingredient was desired.
Film layers of Aquacoat and Eudragit L-30D (commercially available
coating materials) were applied to acetaminophen cores. Amount of coating
material, number of polymer layers, and order of application were varied.
In...
Four different treatments of acetaminophen were administered to
eight healthy volunteers in multiple doses (five doses). Saliva
acetaminophen concentration-time profiles were determined. Non-compartmental
pharmacokinetic parameters for the first and last dose
were calculated and compared to determine whether acetaminophen
exhibited linear or dose dependent pharmacokinetics. Dose corrected
area under the...
The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
Gastrointestinal (GI) transit data were collected using pigs
as animal models. Density and size effects of non-disintegrating
dosage forms on GI transit were investigated. Total GI transit
times range from 2 to 33 days for 22 administrations of these nondisintegrating
dosage forms. Pigs are found to not be an
appropriate...