Index Catalog // ScholarsArchive@OSU

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: formulation and 507 in vitro dyphylline released within the first hour from a polymer matrix formulation

Tablet shapes and in vitro evaluation of coated hydrophilic matrix tablets novel mupirocin formulations non-acidic enteric coating of omeprazole and novel hot-melt coating process

Creator:: Leung, Manshiu
Abstract:: This dissertation is comprised of four distinct formulation sections, which are described below: A novel solid dosage formulation was investigated for achieving zero-order drug release profile by combining tablet shape design and tablet membrane film coating. Verapmail (model drug) was compressed into hydrophilic matrix tablet cores of flat-faced and bi-convex...
Resource Type:: Dissertation
Full Text:: Omeprazole; and Novel Hot-Melt Coating Process. Abstract approved: James W This dissertation is comprised

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Creator:: Laskar, Paul A.
Abstract:: The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was investigated in several buffered aqueous media, in mixed solvent and in nonaqueous solvent systems, and in the presence of several electrolytes and nonelectrolytes. The degradation rate constant of BCNU in these systems was calculated from the parameters of the linear regression of...
Resource Type:: Dissertation
Full Text:: privacy Dr. James W. All The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was

Development and in vivo testing of a gastric retention device (GRD) in dogs

Creator:: Kapsi, Shivakumar G.
Abstract:: This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
Resource Type:: Dissertation
Full Text:: Testing of a Gastric Retention Device (GRD) in dogs, 2) Product Formulations and In Vitro-In Vivo

Development of Hot-melt Pan-coating, Application to Sustained-release Capsules and Tamper Resistant-coating. 2) Formulation of Verapamil HCl and Diltiazem HCl Semisolid Matrix Capsules. 3) Novel Sustained Release Tablet of Glipizide: Compression of Coated Drug Beads, Formulation, Dissolution, and Convolution. 4) Verapamil Sustained Release: New Formulation and Convolution

Creator:: Nguyen, Chien Ngoc
Abstract:: Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
Resource Type:: Dissertation
Full Text:: approved: James W. Ayres J. Mark Christensen Hot-melt pan-coating, which is a novel

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: . Abstract approved: James W. Ayres This dissertation presents a research series

Development and evaluation of a sustained release amoxicillin dosage form

Creator:: Ge, Yan, 1962-
Resource Type:: Masters Thesis
Full Text:: Development and evaluation of a sustained release amoxicillin

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Creator:: Anderson, John L.
Resource Type:: Masters Thesis
Full Text:: Pharmacokinetic investigation of a potential drug

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Creator:: Ahmed, Iman Saad
Abstract:: This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
Resource Type:: Dissertation
Full Text:: . CHAPTER 1 Release and Gastric Retentive Properties of a Gastric Retention Device Iman S. Abmed and James

Product formulations and in vitro-in vivo evaluation of a novel "Tablet-in-a-Bottle" suspension formulation of amoxicillin and clavulanic acid

Creator:: Yang, Ning-Ning
Abstract:: This thesis describes a novel "Tablet-in-a-Bottle" oral suspension formulation. Ingredients with unstable physical or chemical characteristics can be placed in a core tablet, and then dry compression coated with an outer layer which provides separation from other components. The new suspension formulation comprises fast disintegrating clavulanic acid (KCA) tablets with...
Resource Type:: Masters Thesis
Full Text:: Product formulations and in vitro-in vivo evaluation of a

ScholarsArchive@OSU

New product formulations, pharmacokinetics and bioavailability of dyphylline

Tablet shapes and in vitro evaluation of coated hydrophilic matrix tablets novel mupirocin formulations non-acidic enteric coating of omeprazole and novel hot-melt coating process

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Development and in vivo testing of a gastric retention device (GRD) in dogs

The study of pharmacokinetics in a clinical environment

Development and evaluation of a sustained release amoxicillin dosage form

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Product formulations and in vitro-in vivo evaluation of a novel "Tablet-in-a-Bottle" suspension formulation of amoxicillin and clavulanic acid

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