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Filtering by: Creator Koski, James R. Remove constraint Creator: Koski, James R. Advisor Ayres, James W. Remove constraint Advisor: Ayres, James W.

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  • Assay and pharmacokinetics of dyphylline following oral administration in humans

    Creator:
    Gisclon, Lee Gehl
    Abstract:
    Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
    Resource Type:
    Masters Thesis
    Full Text:
    ORAL ADMINISTRATION IN HUMANS Abstract approved: Redacted for privacy James W. Ayr4s(e7.D. Improved

  • The absolute bioavailability of dyphylline tablets in human subjects

    Creator:
    Huston, Thomas K.
    Abstract:
    Dyphylline has been shown to be rapidly and completely absorbed from oral tablets in an absolute bioavailability study. In a pilot study two healthy male subjects received 1000 mg of dyphylline via intravenous infuson at a rate of 50 mg/min (1.0 ml/min) for 20 minutes. Plasma samples were collected for...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: Redacted for Privacy 0 James W. Ayres,(PV.D. Dyphylline has been shown to be rapidly

  • Chelating agents in the drug dosage design of iron preparations

    Creator:
    Ghannam, Musa
    Abstract:
    The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
    Resource Type:
    Masters Thesis
    Full Text:
    , Redacted for Privacy / Dr. James R. Ayre'V Abstract approved: The role of iron in the body is well known

  • Prolonged duration of action of dyphylline through prodrugs

    Creator:
    Panomvana, Duangchit
    Resource Type:
    Dissertation
    Full Text:
    . Redacted for privacyAbstract approved: ?'Dr. James W. Ayres A series of four diesJrs and four monoesters

  • Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

    Creator:
    Huang, Hua-pin
    Abstract:
    Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
    Resource Type:
    Dissertation
    Full Text:
    function to the stomach C s Prodrug concentration in the stomach R s : Prodrug mass transport rate

  • Pharmacokinetic/pharmacodynamic modeling/simulation and novel gastric retention formulation

    Creator:
    Kwon, Hyojong
    Abstract:
    This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
    Resource Type:
    Dissertation
    Full Text:
    /PHARMACODYNAMIC MODELING/SIMULATION AND NOVEL GASTRIC RETENTION FORMULATION. Abstract approved: James W. Ayres

  • Development and in vivo testing of a gastric retention device (GRD) in dogs

    Creator:
    Kapsi, Shivakumar G.
    Abstract:
    This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
    Resource Type:
    Dissertation
    Full Text:
    received from my Prof. James W. Ayres during my graduate studies. I consider myself privileged to have

  • Comparative pharmacokinetic studies of dyphylline and some dyphylline prodrugs

    Creator:
    Huang, Hua-pin
    Abstract:
    Dyphylline is an analog of theophylline and the latter is the most popular member of the methylxanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life has made it's clinical usefulness limited. To avoid this problem a...
    Resource Type:
    Masters Thesis
    Full Text:
    ....- v,....- ,-...- Dr. James W. Ayre i Dyphylline is an analog of theophylline and the latter is the

  • New product formulations, pharmacokinetics and bioavailability of dyphylline

    Creator:
    Chang, Shyi-Feu
    Abstract:
    Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
    Resource Type:
    Dissertation
    Full Text:
    of U.V. absorbance versus standard dyphylline concentrations (Figure 1.1; tables 1.1,2). Typical R

  • Development and evaluation of a sustained release amoxicillin dosage form

    Creator:
    Ge, Yan, 1962-
    Resource Type:
    Masters Thesis
    Full Text:
    . James W. Ayres. Who was the instructor of my first class I took in the US. That class gave me the