Index Catalog // ScholarsArchive@OSU

Pharmacokinetics of theophylline and it's N-7 derivatives in rabbits

Creator:: Tavipatana, Wattanaporn
Abstract:: Pharmacokinetics of theophylline and N-7 substituted theophylline in rabbits when administered alone and in various combinations were investigated. This thesis has four chapters dealing with etophylline and theophylline; proxyphylline and theophylline; dyphylline and theophylline; and etophylline, proxyphylline and dyphylline pharmacokinetics when administered concomitantly. All chapters are interrelated. Each chapter has...
Resource Type:: Masters Thesis
Full Text:: Pharmacokinetics of theophylline and it's N-7

Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

Creator:: Lorskulsint, Duangchit
Abstract:: The effect of concentration, vehicle and surfactant on the absorption of benzocaine -³H across the rat's rectal mucosa was investigated. Blood radioactivity levels were determined after the application of benzociane -³H containing suppositories and ointments. A wet oxidation method was used for sample digestion. Since the radioactivity counted is the...
Resource Type:: Masters Thesis
Full Text:: degree of methemoglobin formation was investigated by the application of 20% benzocaine -3H H n Poly

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Creator:: Rakkanka, Vipaporn
Abstract:: This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
Resource Type:: Dissertation
Full Text:: Oral Formulations, (3) A Novel Zero Order Release Matrix Tablet. Abstract approved James W This

Prolonged duration of action of dyphylline through prodrugs

Creator:: Panomvana, Duangchit
Resource Type:: Dissertation
Full Text:: . Redacted for privacyAbstract approved: ?'Dr. James W. Ayres A series of four diesJrs and four monoesters

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Creator:: Watanalumlerd, Prapoch
Abstract:: Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
Resource Type:: Dissertation
Full Text:: Formulations 3) Development of Leaky Enteric-Coated Pellets Formulations Abstract James W. Effects of

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: . Abstract approved: James W. Ayres This dissertation presents a research series

Product formulations and in vitro-in vivo evaluation of 1) topical insect repellent formualtions against mosquitoes; 2) oral sustained release formulations of cefaclor and pentoxifylline in adults

Creator:: Chou, Joyce Tian-wei
Resource Type:: Dissertation
Full Text:: materialized. The enthusiasm and optimism of my advisor, Dr. James Ayres, who makes this research an

Formulation and in vitro-in vivo evaluation of a new compression-coated tablet of amoxicillin/clavulanate and formulation potential of the antimicrobial peptide nisin

Creator:: Bani Jaber, Ahmad Kh.
Abstract:: This thesis is compromised of two distinct formulation sections, which are described below: New compression-coated tablet formulations were developed for amoxicillin/clavulanate. Amoxicillin in an outer coat was separated from clavulanic acid in a core tablet by inactive ingredients in a middle coat. A chewable compression-coated tablet formulation with 50% stearic...
Resource Type:: Dissertation
Full Text:: Peptide Nisin jAbstract Approved: James W. Ay es of two distinct formulation sections, which are This

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
Resource Type:: Dissertation
Full Text:: , J. M. Parker and J. K. W. Ferguson, J. Pharmacol. Exp. Ther. 116, 343 (1956) . 4, N. Svedmyr, Scand

ScholarsArchive@OSU

Pharmacokinetics of theophylline and it's N-7 derivatives in rabbits

Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

New product formulations, pharmacokinetics and bioavailability of dyphylline

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Prolonged duration of action of dyphylline through prodrugs

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

The study of pharmacokinetics in a clinical environment

Product formulations and in vitro-in vivo evaluation of 1) topical insect repellent formualtions against mosquitoes; 2) oral sustained release formulations of cefaclor and pentoxifylline in adults

Formulation and in vitro-in vivo evaluation of a new compression-coated tablet of amoxicillin/clavulanate and formulation potential of the antimicrobial peptide nisin

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

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