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New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: of U.V. absorbance versus standard dyphylline concentrations (Figure 1.1; tables 1.1,2). Typical R

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Creator:: Hossain, Mohammad
Abstract:: Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate...
Resource Type:: Dissertation
Full Text:: Novel Oral Acetaminophen Product Formulation. Abstract approved: ,Redacted for Privacy James W. Ayres

New product formulations and pharmacokinetics of acetaminophen

Creator:: Borin, Marie T.
Resource Type:: Dissertation
Full Text:: linear regression (r > 0.9996), and used to determine drug concentration in the dissolution samples

Bioadhesive polymers in drug product formulations

Creator:: Tavipatana, Wattanaporn
Abstract:: Gastric retention time of single unit dosage forms in swine was found to be much longer than in humans. It was concluded that swine are not a good animal model to study GI transit time of nonerodable or slowly eroded dosage forms. Noneradable and slowly eroded dosage forms used to...
Resource Type:: Dissertation
Full Text:: approved: _Redacted for Privacy ((/ James W. Ayres, Ph /. / Gastric retention time of single unit dosage

Pharmacokinetic modeling of theophylline and dyphylline and pharmacodynamics of ibuprofen input rate on antipyresis

Creator:: Stevens, Ruth E.
Abstract:: Pharmacokinetic parameters for theophylline and dyphylline were evaluated in horse cerebrospinal fluid (csf) and plasma. Pharmacokinetic parameters did not differ significantly (p > 0.05) at the same dose for either drug when administered alone or concomitantly. Theophylline and dyphylline penetrate horse csf to produce approximately 1/2 the concentrations found in...
Resource Type:: Dissertation
Full Text:: addition, I would like to thank: Dr. James W. Ayres, my major advisor, for his guidance, valuable advice

Assay and pharmacokinetics of dyphylline following oral administration in humans

Creator:: Gisclon, Lee Gehl
Abstract:: Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
Resource Type:: Masters Thesis
Full Text:: ORAL ADMINISTRATION IN HUMANS Abstract approved: Redacted for privacy James W. Ayr4s(e7.D. Improved

The absolute bioavailability of dyphylline tablets in human subjects

Creator:: Huston, Thomas K.
Abstract:: Dyphylline has been shown to be rapidly and completely absorbed from oral tablets in an absolute bioavailability study. In a pilot study two healthy male subjects received 1000 mg of dyphylline via intravenous infuson at a rate of 50 mg/min (1.0 ml/min) for 20 minutes. Plasma samples were collected for...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: Redacted for Privacy 0 James W. Ayres,(PV.D. Dyphylline has been shown to be rapidly

Chelating agents in the drug dosage design of iron preparations

Creator:: Ghannam, Musa
Abstract:: The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
Resource Type:: Masters Thesis
Full Text:: , Redacted for Privacy / Dr. James R. Ayre'V Abstract approved: The role of iron in the body is well known

Prolonged duration of action of dyphylline through prodrugs

Creator:: Panomvana, Duangchit
Resource Type:: Dissertation
Full Text:: . Redacted for privacyAbstract approved: ?'Dr. James W. Ayres A series of four diesJrs and four monoesters

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
Resource Type:: Dissertation
Full Text:: function to the stomach C s Prodrug concentration in the stomach R s : Prodrug mass transport rate

ScholarsArchive@OSU

New product formulations, pharmacokinetics and bioavailability of dyphylline

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

New product formulations and pharmacokinetics of acetaminophen

Bioadhesive polymers in drug product formulations

Pharmacokinetic modeling of theophylline and dyphylline and pharmacodynamics of ibuprofen input rate on antipyresis

Assay and pharmacokinetics of dyphylline following oral administration in humans

The absolute bioavailability of dyphylline tablets in human subjects

Chelating agents in the drug dosage design of iron preparations

Prolonged duration of action of dyphylline through prodrugs

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

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