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Filtering by: Creator Wong, George Kaon Remove constraint Creator: Wong, George Kaon Advisor Bailey, George S. Remove constraint Advisor: Bailey, George S.

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  • Analysis of ras gene mutations in rainbow trout tumors

    Creator:
    Chang, Yung-jin
    Abstract:
    For ras gene mutation analysis in the rainbow trout (Oncorhynchus mykiss) model system, a partial trout ras sequence was identified using the polymerase chain reaction (PCR). Two synthetic oligonucleotides based on rat K-ras gene sequence were used as primers for the PCR procedure. A 90 base pair (bp) sequence, referred...
    Resource Type:
    Dissertation
    Full Text:
    Tumors. Abstract approved : Redacted for Privacy George S. Bailey For ras gene mutation analysis in

  • Site-specific aflatoxin B₁ adduction of sequence-positioned nucleosome core particles

    Creator:
    Moyer, Richard A.
    Abstract:
    The question of how the presence of nucleosomal packing of DNA modifies carcinogen interaction at specific sites cannot be answered by studies on whole chromatin or bulk nucleosomes because of the heterogeneity of DNA sequences in the particles. This problem was circumvented by constructing nucleosomes that are homogenous in DNA-histone...
    Resource Type:
    Dissertation
    Full Text:
    privacy George T. Bailey The question of how the presence of nucleosomal packing of DNA modifies

  • Characterization of a ras gene in rainbow trout

    Creator:
    Mangold, Kathy A.
    Abstract:
    The rainbow trout (Oncorhynchus mykiss) model of chemical carcinogenesis is becoming increasingly important as a supplement to rodent studies. However, much of the molecular biology of the carcinogenic response is still unknown in the trout model. The ras gene family has been implicated in the tumorigenesis of both spontaneous and...
    Resource Type:
    Dissertation
    Full Text:
    : Redacted for Privacy C1 George S. Bailey, Major Professor The rainbow trout (Oncorhynchus mykiss) model

  • Mechanisms of action by some inhibitors of aflatoxin B₁ carcinogenesis in rainbow trout

    Creator:
    Goeger, Douglas Eugene
    Abstract:
    Indole-3-carbinol (I3C) and butylated hydroxyanisole (BHA), anti-carcinogens present in the human diet, were tested for their in vivo and in vitro effect on aflatoxin B₁. (AFB₁) metabolism, and DNA adduct formation in the rainbow trout. Dietary BHA at either 0.3 or 0.03% had no effect on the hepatic tumor incidence...
    Resource Type:
    Dissertation
    Full Text:
    approved: _ x. George S. Bailey Indole-3-carbinol (I3C) and butylated hydroxyanisole (BHA), anti

  • Chlorophyllin anticarcinogenesis in the rainbow trout model

    Creator:
    Breinholt, Vibeke
    Resource Type:
    Dissertation
    Full Text:
    approved by : George S. Bailey Chlorophyl lin (CHL), a derivative of the green plant pigment chlorophyll