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Filtering by: Creator Sanson-Barrera, Anna Remove constraint Creator: Sanson-Barrera, Anna Advisor Barbar, Elisar Remove constraint Advisor: Barbar, Elisar

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  • Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

    Creator:
    Estelle, Aidan B.
    Abstract:
    Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...
    Resource Type:
    Dissertation
    Full Text:
    contributed heavily to the analysis, writing and editing of the chapter. Anna Akhmanova and York-Christoph

  • Viral Targeting of Host Hubs: Interactions between the Rabies Virus and LC8

    Creator:
    Jespersen, Nathan E.
    Abstract:
    As obligate intracellular parasites, viruses rely on host machinery for their own reproduction. Viruses are therefore required to interact with a wide variety of host proteins, despite limitations in viral genome size. The most parsimonious method of success is to hijack central and essential proteins, known as hub proteins. LC8...
    Resource Type:
    Dissertation
    Full Text:
    performed phage display experiments from Chapter 3. Anna Akhmanova and York-Christoph Ammon collected cell