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Filtering by: Creator O'Dea, Annika Advisor Buermeyer, Andrew

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:

Kernan, Casey P.

Abstract:

DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...

Resource Type:

Honors College Thesis

Full Text:

V. Characterization of HPRT Mutants…………………………………………………39 Summary of Conclusions and Future
Mismatch Repair-Dependent Cellular Responses to Polycyclic Aromatic Hydrocarbons: An Investigation of Research Methods and Materials

Creator:

Wickramanayake, Anneka

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic chemical compounds found in the environment, largely as a result of partial combustion of organic compounds. PAHs are present in the atmosphere in populated cities worldwide. Because of the health risks they create, PAHs are a global health concern. PAHs are introduced into the...

Resource Type:

Honors College Thesis