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  • Transdermal Delivery of Atenolol to Cats

    Creator:
    Mohamed, Sumeia M.
    Abstract:
    This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ John M. Christensen This thesis describes in-vitro and in-vivo evaluation of a transdermal

  • Application of Bootstrap Methods in Bioequivalence Studies for Oral Generic Prodrug Products

    Creator:
    Li, Wenjing
    Abstract:
    The methodology to perform bioequivalence studies for prodrug products has not been finalized by FDA leaving the investigators to speculate over the proper approach. This study innovatively utilized the bootstrap methods for testing in vivo bioequivalence on both parent drug and metabolite of four prodrug products: Clopidogrel, Prednisone, Allopurinol, and...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ John Mark Christensen The methodology to perform bioequivalence studies for prodrug

  • Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets

    Creator:
    Sartnurak, Soisurin
    Abstract:
    Dissolution profiles of two commercial products (Motrine and Rufen®) were analyzed and compared at 8 pH levels, ranging from pH 2.0 to pH 8.0. It was demonstrated, as expected, that the rate and extent of ibuprofen dissolution dissolution was pH dependent. In vitro dissolution characteristics of the ibuprofen solid dispersion...
    Resource Type:
    Dissertation
    Full Text:
    Formulation of Oral Ibuprofen Tablets Abstract approved: L. -,, , ..,-...--- John M. Christensen, Ph.D

  • Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

    Creator:
    Suvanakoot, Uthai
    Abstract:
    A two-part study was conducted with three poorly water soluble drugs (phenylbutazone, tolbutamide, theophylline) to develop two new drug delivery systems based on physical-chemical approaches. In the first part, tolbutamide and phenylbutazone were made into solid dispersions with various excipients using a lyophilization technique. In vitro dissolution studies of these...
    Resource Type:
    Dissertation
    Full Text:
    Chulalongkorn University for full financial support throughout my study, and to Dr. John M. Christensen and Dr

  • Development of novel oral enteric-coated aquaculture vibrio vaccines

    Creator:
    Wong, George Kaon
    Abstract:
    An oral Vibrio vaccine for salmonids was developed. The vaccine was produced by spray coating lyophilized formalin-killed whole cells of Vibrio anguillarum (VA LS 1- 74) onto non-pareil sugar beads. Then methacrylic acrylic acid copolymer (Eudragit L-30D) was applied as an enteric protective coating. Using x-ray radiographic techniques, it was...
    Resource Type:
    Dissertation
    Full Text:
    Aquaculture Vibrio Vaccines Abstract approved: 114edaatecr 4for Privacy ohn M. Christensen, Ph.D. An oral