Indole-3-carbinol (13C), a metabolite of glucobrassicin, is found in cruciferous vegetables. It is able to act as an inhibitor or promoter of carcinogenesis depending on the species, the carcinogen and when it is given in relation to the carcinogen. This is probably due to the fact that it reacts in...
Cell lines deficient in certain genes of the DNA mismatch repair (MMR) system show a marked resistance to the cell killing or apoptotic effects of DNA alkylating agents. The molecular mechanism for this resistance is not yet understood, but is currently of great interest because of the recent use of...