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Filtering by: Creator Oakley, Brian B. Remove constraint Creator: Oakley, Brian B. Advisor Gerwick, William H. Remove constraint Advisor: Gerwick, William H.

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  • Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

    Creator:
    Marquez, Brian L.
    Abstract:
    This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE THESIS OF Brian L. Marguez for the degree of

  • Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

    Creator:
    Han, Bingnan
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
    Resource Type:
    Dissertation
    Full Text:
    and B were approximately 10-fold more toxic than C and 0 to these cell lines. Lyngbya majuscula has

  • Natural products from tropical and temperate marine algae

    Creator:
    Bernart, Matthew W.
    Abstract:
    Following surveys of seaweeds in Oregon and the Caribbean, four algal species were selected for study on the basis of their crude extract biological activity or thin-layer chromatographic characteristics. Extracts were fractionated by normal phase chromatography, including high performance liquid chromatography (HPLC). Derivatives (methyl esters, acetates, and benzoates) of natural...
    Resource Type:
    Dissertation
    Full Text:
    me through all these years. In Agricultural Chemistry, Brian Arbogast and Don Griffin provided us

  • Bioactive natural products from marine algae

    Creator:
    Tan, Lik Tong
    Abstract:
    This thesis is an account of my investigation on the natural products deriving from various marine algae and has resulted in the discovery of thirteen novel bioactive metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D...
    Resource Type:
    Dissertation
    Full Text:
    several novel cyclic depsipeptides, given the trivial names clairamides A and B, wewakamide, carliamide

  • Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

    Creator:
    Yoo, Hye-Dong
    Abstract:
    My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. Two new and potent antimitotic metabolites, curacins B and C, were isolated...
    Resource Type:
    Dissertation
    Full Text:
    antimitotic metabolites, curacins B and C, were isolated from a Curacao collection of Lyngbya majuscula. In

  • Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

    Creator:
    Nogle, Lisa Marie
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
    Resource Type:
    Dissertation
    Full Text:
    isolates were the novel sodium channel blocker antillatoxin B, a new chlorinated quinoline derivative and

  • Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

    Creator:
    Milligan, Kenneth Edward
    Abstract:
    This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...
    Resource Type:
    Dissertation
    Full Text:
    lyngbyabellin B were isolated as toxic cyclic depsipeptides. Both of these compounds displayed relatively

  • Natural products studies of the marine cyanobacterium Lyngbya majuscula

    Creator:
    Sitachitta, Namthip
    Abstract:
    The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...
    Resource Type:
    Dissertation
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    depsipeptides, yanucamides A and B. Both compounds possessed the unique 2,2-dimethyl-3-hydroxy-7-octynoic acid

  • New bioactive natural products from marine algae and cyanobacteria

    Creator:
    Sabry, Omar Mohamed
    Abstract:
    This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
    Resource Type:
    Dissertation
    Full Text:
    resulted in the isolation of three new compounds; (+) curcuepoxide A, (+) curcuepoxide B and (+)-lOa

  • Novel bioactive secondary metabolites from the marine cyanobacterium Lyngbya majuscula

    Creator:
    Wu, Min, 1963-
    Abstract:
    Marine algae have been recognized as a rich resource of new and unusual organic molecules with diverse biological properties. The current need to develop new antifungal, anticancer, antibiotic and antiviral drugs has led to an intense research effort into the discovery, isolation and structure determination of potential medicinal agents from...
    Resource Type:
    Masters Thesis
    Full Text:
    people for their technical assistance in my graduate research: Brian Arbogast for his providing the