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Filtering by: Alternative title ssim EC 1102 Remove constraint Alternative title ssim: EC 1102 Advisor Hagen, Tory M. Remove constraint Advisor: Hagen, Tory M.

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Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Creator:

Smith, Anthony R.

Abstract:

The vascular endothelium is a single cell layer that lines the lumen of the entire vasculature. It is the site of synthesis of nitric oxide (NO), a vasodilatory compound synthesized by endothelial nitric oxide synthase (eNOS). NO causes intracellular calcium sequestration of the vascular smooth muscle cells, relaxing and dilating...

Resource Type:

Dissertation
Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Creator:

Thomas, Nicholas O.

Abstract:

Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...

Resource Type:

Dissertation
Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:

Smith, Eric Jonathan

Abstract:

Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...

Resource Type:

Dissertation
The aging endoplasmic reticulum

Creator:

Dixon, Brian M.

Abstract:

Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...

Resource Type:

Dissertation

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Academic Affiliation

Biochemistry and Biophysics2

Advisor

Hagen, Tory M.[remove]4

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2005 to 2018

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Committee Member

Frei, Balz3
Beckman, Joe1
Boyer, Charles1
Cannon, Matthew J.1
Gombart, Adrian F.1
more Committee Members »

Creator

Dixon, Brian M.1
Smith, Anthony R.1
Smith, Eric Jonathan1
Thomas, Nicholas O.1

Date

Date range begin – Date range end

Current results range from 2005 to 2017

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Decade

2010-20192
2000-20092

Degree Field

Biochemistry and Biophysics2
Molecular and Cellular Biology2

Degree Level

Doctoral4

Degree Name

Doctor of Philosophy (Ph.D.)4

File Format

application/pdf1

Language

English [eng]4

License

All rights reserved4

Non-Academic Affiliation

Oregon State University. Graduate School4

Peer Reviewed

No4

Resource Type

Dissertation4

Rights Statement

In Copyright4

Subject

Glutathione2
Oxidative stress2
Aging -- Molecular aspects1
Antioxidants1
Cells -- Aging1
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