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Filtering by: Creator Cox, Robin Remove constraint Creator: Cox, Robin Advisor Ho, Pui Shing Remove constraint Advisor: Ho, Pui Shing

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  • Analyses of noncanonical DNA structures

    Creator:
    Khuu, Patricia A.
    Abstract:
    The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical in protein recognition and manipulation. In particular, it can form Holliday junctions, four-way DNA structural...
    Resource Type:
    Dissertation
    Full Text:
    four-way DNA junction was first proposed by Robin Holliday in 1964 as the central structural

  • Crystal structures of DNA four-way junctions

    Creator:
    Eichman, Brandt F.
    Abstract:
    DNA four-way junctions (also known as Holliday junctions) are the primary structural intermediate during recombination, an important process responsible for biological evolution and maintenance of genomes. These junctions arise from the assembly of four nucleic acid strands to produce double-helical regions extending from a central point. Although much progress has...
    Resource Type:
    Dissertation
    Full Text:
    DNA junction, first proposed by Robin Holliday in 1964 to explain homologous recombination, is now

  • Sequence dependent conformational variations in DNA holliday junctions

    Creator:
    Hays, Franklin A.
    Abstract:
    Four-stranded DNA junctions (also known as Holliday junctions) are structural intermediates involved in a growing number of biological processes including DNA repair, genetic recombination, and viral integration. Although previous studies have focused on understanding the conformational variability and sequence-dependent formation of Holliday junctions in solution there have been relatively few...
    Resource Type:
    Dissertation
    Full Text:
    Introduction Four-stranded DNA junctions were first proposed by Robin Holliday in 1964 to explain abnormal