Index Catalog // ScholarsArchive@OSU

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Creator:: Page, Jessica M.
Abstract:: An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic proteolysis step of the vaccinia virus life cycle. The vvtetO:I7L/G1L controlled the expression of two genes, I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the maturation of viral core proteins, p4a, p4b,...
Resource Type:: Honors College Thesis
Full Text:: THESIS OF Jessica M. Page for the degree of Honors Baccalaureate of Science in Biochemistry and

Vaccinia virus I7L core protein proteinase

Creator:: Byrd, Chelsea M.
Abstract:: Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Chelsea M. Byrd for the

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

Creator:: Martin, Karen H.
Abstract:: The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
Resource Type:: Dissertation
Full Text:: protein did not fit the consensus sequence for N-myristylation (M-G-X-X-X- S/T/A/C/N), suggesting that it

Host cell nuclear involvement in vaccinia virus replication

Creator:: Villarreal, Elcira C.
Abstract:: It was previously shown that vaccinia virus is unable to complete its replicative cycle in cells that have been subjected to cytochalasin-B mediated enucleation prior to infection. Likewise, in the presence of the drug α-amanitin, a potent inhibitor of host RNA polymerase II but not of viral transcription, the replication...
Resource Type:: Dissertation
Full Text:: HindIII-M fragments as well as the strategy used in sequencing this region of the genome Figure IV.2

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Creator:: Ravanello, Monica P. G.
Resource Type:: Dissertation
Full Text:: at the amino-terminus has been determined and may be summarized as follows: (M -) G (A/S/V/G/L) X X

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Creator:: Child, Stephanie J.
Abstract:: Vaccinia virus (VV), the prototype member of the orthopoxvirus family, is a large virus of complex morphology which contains a 191 Kbp double-stranded DNA genome whose expression is tightly regulated in a temporal fashion during viral replication. The regulation of gene expression can be exerted at various of levels, including...
Resource Type:: Dissertation
Full Text:: kinetics of EEV fusion are more rapid than for the INV virus (Doms et al., 1990; Payne and Norrby, 1978

Proteolytic maturation of vaccinia virus virion-associated proteins : analysis of substrate determinants

Creator:: Lee, Peiyu
Resource Type:: Dissertation
Full Text:: ., 1993; Mangal et al., 1993). A consensus -(M/L/I)-X-G-(G/X)*(X/G)- cleavage motif for proteinase

Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

Creator:: Grosenbach, Douglas W.
Abstract:: Vaccinia virus encodes at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through thioester linkage to cysteine residues. This is referred to as palmitylation of proteins. The purpose of this work was to gain an understanding of palmitylation, focusing on what defined...
Resource Type:: Dissertation
Full Text:: Golgi and the trans-Golgi network (C, M, T, and TGN respectively). The major stages of the virus life

Identification and analysis of vaccinia virus acylproteins

Creator:: Hansen, Scott G.
Abstract:: Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
Resource Type:: Dissertation
Full Text:: -terminus has been determined and may be summarized as the following: (M-) G- (AIS/VIG/L)-X-X-(S/T/A)-. N

Structural and functional dissection of the vaccinia virus thymidine kinase enzyme

Creator:: Black, Margaret E.
Abstract:: Thymidine kinase is a key enzyme in the nucleotide salvage pathway, catalyzing the production of dTMP from thymidine and ATP. In order to identify the structural features of the TK protein and/or primary amino acid sequences which contribute to the catalytic and regulatory activities of this enzyme, an in vitro...
Resource Type:: Dissertation
Full Text:: for thymidylate synthase (M. Slabaugh, personal communication) and therefore is unable to make dTMP

ScholarsArchive@OSU

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Vaccinia virus I7L core protein proteinase

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

Host cell nuclear involvement in vaccinia virus replication

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Proteolytic maturation of vaccinia virus virion-associated proteins : analysis of substrate determinants

Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

Identification and analysis of vaccinia virus acylproteins

Structural and functional dissection of the vaccinia virus thymidine kinase enzyme

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