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Filtering by: Creator Kelsey, Rick G. Remove constraint Creator: Kelsey, Rick G. Advisor Karplus, P. Andrew Remove constraint Advisor: Karplus, P. Andrew

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  • Structural Insights into Novel Sugar Phosphate Cyclases and Flavoenzymes

    Creator:
    Kean, Kelsey M.
    Abstract:
    The function of a protein is defined by its three-dimensional structure, and in understanding the three-dimensional structure of a protein, we gain an understanding of its function and mechanism. Protein structures, especially at high resolution, can provide detailed insights into many elements of enzyme function and catalysis – identifying residues...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Kelsey Marie Kean for the degree of Doctor of Philosophy in

  • Structural investigations to understand the mechanisms of two proteins involved in sulfur chemistry : SsuE and cysteine dioxygenase

    Creator:
    Driggers, Camden McCullough
    Abstract:
    Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
    Resource Type:
    Dissertation
    Full Text:
    laboratory equipment, and for training two great scientists, Rick Cooley and Luis Sayavedra-Soto who have

  • Partial Characterization of the Danio rerio and Xenopus tropicalis MT-­‐Ox Enzyme Involved in Gadusol Biosynthesis

    Creator:
    Roemelt, Taylor
    Abstract:
    Ultraviolet (UV)-protective compounds, such as mycosporine-like amino acids (MAA) are critical for the survival of marine organisms exposed to high-solar radiation. A chemically similar compound, gadusol, was discovered in eggs of the atlantic cod in 1980, and was originally thought to be derived from MAAs that had been ingested. However,...
    Resource Type:
    Honors College Thesis
    Full Text:
     and  Biophysics         Kelsey  Kean,  Committee  Member,  representing

  • Crystallographic studies of Pyrenophora tritici-repentis ToxA

    Creator:
    Sarma, Ganapathy N.
    Abstract:
    Tan spot of wheat is an economically significant disease caused by the fungal pathogen, Pyrenophora tritici-repentis. Certain races of the fungus secrete Ptr ToxA (ToxA), a 13.2 kDa proteinaceous host-selective toxin that is responsible and sufficient to cause disease in susceptible wheat varieties. Disease symptoms develop only when the ToxA...
    Resource Type:
    Dissertation
    Full Text:
    Ciuffetti Aishwarya Damodar Vidya Dinesh Kathy Faber Megan Faber Nathan Faber Rick Faber Sonia

  • Exploring Protein Structure: Seeing the Forest and the Trees

    Creator:
    Brereton, Andrew E.
    Abstract:
    Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...
    Resource Type:
    Dissertation
    Full Text:
    needed it, without hesitating. Lastly, I need to thank Kelsey Kean, my friend and peer. Kelsey, firstly

  • Modeling protein structure at atomic resolution

    Creator:
    Berkholz, Donald S.
    Abstract:
    This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...
    Resource Type:
    Dissertation
    Full Text:
    , particularly these: Rick Faber, who shared his in-depth knowledge of the depths of crystallography; Ganapathy

  • Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

    Creator:
    Perkins, Arden
    Abstract:
    Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...
    Resource Type:
    Dissertation
    Full Text:
    thank the members of the Karplus lab— Camden Driggers, Kelsey Kean, and Andrew Brereton—for being such

  • Biophysical analyses of peroxiredoxins and a partner reductase

    Creator:
    Hall, Andrea Renée
    Abstract:
    Peroxiredoxins (Prxs) are dominant peroxide-reducing enzymes with two important roles: they protect all organisms from oxidative damage induced by peroxides, and in eukaryotes, they participate in hydrogen peroxide signaling pathways. This dissertation presents studies aimed at the biophysical characterization of select Prxs and a Prx reductase to elucidate their structure-function...
    Resource Type:
    Dissertation
    Full Text:
    has made my graduate work possible ( I thank Rick Faber. Among the long list of specifics that you