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Filtering by: Committee Member Taylor, Barbara Remove constraint Committee Member: Taylor, Barbara Advisor Kioussi, Chrissa Remove constraint Advisor: Kioussi, Chrissa

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  • Gene Networks of the Skeletal Muscle Cell

    Creator:
    Singh, Arun J.
    Abstract:
    Skeletal muscle is the largest organ in the body by mass, comprising roughly 40% of total bodyweight in adults. It plays diverse and unique roles that include movement, locomotion, and support for posture and internal organs, among others. The structural foundation for all skeletal muscle in adults is formed early...
    Resource Type:
    Dissertation
    Full Text:
    committee, Drs. Stephen Ramsey, Barbara Taylor, and Andriy Morgun, for their support and feedback during

  • Roles of homeodomain transcription factors during organogenesis

    Creator:
    Xu, Jun
    Abstract:
    The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
    Resource Type:
    Dissertation

  • Gene regulatory networks during muscle development

    Creator:
    Eng, Diana G.
    Abstract:
    Congenital myopathies are caused by heritable mutations in particular genes. Genes mutated in congenital muscular dystrophies often encode cytoskeletal proteins, which contribute to the shape and movement of cells. We would like to know how such molecular defects lead to the muscle weakness in patients. It is therefore important to...
    Resource Type:
    Dissertation
    Full Text:
    Sikora – Committee Member Dr. Barbara Taylor – Committee Member The Kioussi Lab The Molecular and

  • Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

    Creator:
    Lattier, Vera C.
    Abstract:
    Skeletal muscle, the largest organ in the body in mass, is composed by 600 specialized muscles in humans with unique biochemical, physiological and metabolic identities. Skeletal muscles control body movement, locomotion, and nutrient balance. Muscle formation requires precisely orchestrated environmental signals and regulatory gene networks in time and space. Gene...
    Resource Type:
    Dissertation
    Full Text:
    this far without her. I thank my committee member Dr. Barbara Taylor, Dr. Fred Stevens, Dr. Mark