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Filtering by: Creator Lange, Sandra L. Remove constraint Creator: Lange, Sandra L. Advisor Loesgen, Sandra Remove constraint Advisor: Loesgen, Sandra

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  • A robust Mycobacterium smegmatis Assay for the Discovery of Anti-tubercular Metabolites from Soil Bacteria

    Creator:
    Chen, Kathryn P
    Abstract:
    Tuberculosis (TB) is a pressing global health issue with approximately one third of the world’s population infected by this bacterium. As one of the most dangerous infectious diseases, it has killed approximately 1.7 million people of all ages around the world per year (World Health Organization, 2016). Currently, several drugs...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Sandra Loesgen Tuberculosis (TB) is a pressing global health issue with

  • Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

    Creator:
    Kaweesa, Elizabeth Namagoba
    Abstract:
    Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: ______________________________________________________ Sandra Loesgen Mensacarcin is a

  • Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

    Creator:
    Zhu, Chenxi
    Abstract:
    Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
    Resource Type:
    Dissertation
    Full Text:
    approved: _____________________________________________________ Sandra Loesgen Exploring bioactive

  • Bioactivity Screening and Gene Activation Strategies in Fungi

    Creator:
    Coddington, Nathan C.
    Abstract:
    Natural products from plants, bacteria, and fungi play an important role in society. Over the last 35 years, natural products and their derivatives have inspired over 60% of all FDA approved small-molecule drugs, and are among the top prescribed therapeutics.1-2 Fleming’s discovery of the fungal antibiotic penicillin started the “Golden...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract approved: ______________________________________________________________ Sandra Loesgen

  • Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

    Creator:
    Neuhaus, George F.
    Abstract:
    The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Sandra Loesgen The study of natural products (NPs) and their application has shaped

  • A Dive into the Pacific Fish Microbiome: Exploration of Antibiotics from a Unique Ecosystem

    Creator:
    Austin, Molly C.
    Abstract:
    With the rise of resistant bacterial pathogens, currently prescribed antibiotics are rendered useless. In recent years, marine natural products (MNPs) have emerged as novel sources for drug leads. The ocean is a complex environment where marine animals cohabitate with many, and sometimes harmful microorganisms and viruses, but resist infections. Developed...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Sandra Loesgen With the rise of resistant bacterial pathogens, currently prescribed

  • Bioprospecting the Chemical Diversity of Plant-associated Fungi

    Creator:
    González-Montiel, Gisela Abigail
    Abstract:
    Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
    Resource Type:
    Masters Thesis
    Full Text:
    : ______________________________________________________ Sandra Loesgen Fungi have long been used for discovery of new chemical scaffolds. In the

  • New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

    Creator:
    Overacker, Ross D.
    Abstract:
    Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
    Resource Type:
    Dissertation
    Full Text:
    : _____________________________________________________ Sandra Loesgen Small molecule drugs have been instrumental in our fight against diseases

  • Isolation, Characterization, and Antibiotic Activity of Fungal Metabolites from an Algal Endophyte

    Creator:
    Stoumbos, Demetri
    Abstract:
    Pseudomonas aeruginosa is a gram-negative nosocomial pathogenic bacterium known for its resilience against antibiotics. The bacterium infects over 50,000 patients each year in the United States, with 13% of reported cases involving multi-drug-resistant strains of Pseudomonas. This research discovered several fungal natural products with promising activity against Pseudomonas aeruginosa. The...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract approved: ______________________________________________________ Sandra Loesgen

  • Fungal endophytes as source to combat bacterial infections

    Creator:
    Green, Jaimie R
    Abstract:
    Endophytes, foliage inhabiting fungi, are an unexplored source of fungal biodiversity and a potential resource for the production of bioactive natural products. In this research, leaf tissues from the species Arbutus menziesii, Rhododendron macrophyllum and the genus, Ilex and Salix were collected for the isolation of endophytic fungi. Fungal extracts...
    Resource Type:
    Presentation and Undergraduate Thesis
    Full Text:
    _____________________________________________________ ______________ Sandra Loesgen, Chemistry