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Filtering by: Creator Perilli, L. Paige Remove constraint Creator: Perilli, L. Paige Advisor Loesgen, Sandra Remove constraint Advisor: Loesgen, Sandra

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  • Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

    Creator:
    Zhu, Chenxi
    Abstract:
    Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
    Resource Type:
    Dissertation
    Full Text:
    colleagues: Dr. Donovon Adpressa, Dr. Ross Overacker, George Neuhaus, Paige Mandelare and Elizabeth

  • A Dive into the Pacific Fish Microbiome: Exploration of Antibiotics from a Unique Ecosystem

    Creator:
    Austin, Molly C.
    Abstract:
    With the rise of resistant bacterial pathogens, currently prescribed antibiotics are rendered useless. In recent years, marine natural products (MNPs) have emerged as novel sources for drug leads. The ocean is a complex environment where marine animals cohabitate with many, and sometimes harmful microorganisms and viruses, but resist infections. Developed...
    Resource Type:
    Honors College Thesis
    Full Text:
    thank you to my graduate student mentor, Paige E. Mendalare, for going above and beyond to assist in my

  • Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

    Creator:
    Neuhaus, George F.
    Abstract:
    The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
    Resource Type:
    Dissertation
    Full Text:
    ) Zhu, Paige Mandelare, and Elizabeth Kaweesa. May we remain close throughout the future. My