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Filtering by: Creator Cox, Jane Remove constraint Creator: Cox, Jane Advisor Mahmud, Taifo Remove constraint Advisor: Mahmud, Taifo

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  • Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

    Creator:
    Sheng, Yan
    Abstract:
    The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
    Resource Type:
    Dissertation
    Full Text:
    Proteau, Dr. Jane Ishmael and Dr. Adrian Gombart for their generous time, support, advice and

  • Development and testing of novel anti-tubercular drugs

    Creator:
    Almabruk, Khaled Husain G.
    Abstract:
    Tuberculoѕiѕ (TB) iѕ a number one killer among treatable infectious diseases. It is caused by the pathogenic bacterium Mycobacterium tuberculoѕiѕ that primarily affects the lungѕ. It infects one third of the world population and kills approximately 2 million people each year (based on WHO report). Drug-reѕiѕtant TB haѕ become a...
    Resource Type:
    Masters Thesis
    Full Text:
    . I would like to thank my graduate committee members, Dr. Mark Zabriskie, Dr. Jane Ishmael, Dr

  • Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

    Creator:
    Eida, Auday
    Abstract:
    Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
    Resource Type:
    Dissertation
    Full Text:
    members: Dr. Kerry McPhail, Dr. Benjamin Philmus, Dr. Jane Ishmael, and Dr. Daniel Rocky for their

  • Biosynthesis and Rational Design of Novel Pactamycin Analogs

    Creator:
    Abugrain, Mostafa E.
    Abstract:
    Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
    Resource Type:
    Dissertation
    Full Text:
    , and did the antibacterial assay, as well as cloned and expressed the ptmD gene. Dr. Jane Ishmael did

  • Development of Novel Agents to Combat Tuberculosis and Malaria

    Creator:
    Almabruk, Khaled Husain G.
    Abstract:
    Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
    Resource Type:
    Dissertation
    Full Text:
    double knockout mutant ptmT/H, and Drs. Yuexin Li and Jane X. Kelly did the anti-malarial assay. Khaled