Methane is a flammable gas that is the main component of natural gas. It is a highly potent greenhouse gas, and accounts for about 20% of greenhouse gas emissions. Methane is routinely flared in many industrial processes without harnessing any of its energy. The environmental impact and wasted energy potential...
Sepsis is a blood infection that is caused by circulating bacteria cells and cell fragments, which contain immunogenic lipopolysaccharides (LPS) or endotoxin. The circulating endotoxin results in a severe dysregulation of the inflammatory response that ultimately leads to organ failure. One promising treatment method is removal of endotoxin by passing...
Sepsis, caused by bacterial release of endotoxin, is a serious blood infection that causes uncontrolled systemic immune response. In North America alone, sepsis kills between 220,000 and 380,000 people each year, more than prostate cancer, breast cancer, and HIV/AIDS combined. Sepsis treatment is complicated and often requires prolonged hospital stays,...
Sepsis is a life-threatening blood infection which leads to an uncontrolled systemic inflammatory state. In North America alone, sepsis annually afflicts approximately 750,000 individuals and kills 38-50% of these (more than HIV/AIDS, breast cancer, and colon cancer combined). Current treatment involves administration of IV fluids, antibiotics and hemoperfusion, requiring prolonged...
Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...